Recurrence in pituitary adenomas in childhood and adolescence

A. J. Espay, B. Azzarelli, Linda Williams, J. B. Bodensteiner

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Pediatric pituitary adenomas are thought to behave more aggressively than their adult counterparts, and the ability to predict the degree of such behavior remains elusive. Proliferation marker Ki-67 and tumor suppressor gene p53 mutations have been used in adults to assist in the evaluation of invasiveness and recurrence; however, their use in childhood and adolescence remains anecdotal. Our study evaluates the proliferative potential in pituitary adenomas of five patients and its relationship with recurrence or persistence of endocrinologic or clinical abnormalities. For such assessment, tissues were stained with monoclonal antibodies BP53-12 for p53 tumor suppressor gene mutation and MIB-1, which binds to cell cycle-specific nuclear antigen Ki-67. In our series, one patient with recurrent adenoma demonstrated the highest (50%) p53 immunoreactivity. Ki-67-stained nuclei ranged from 0 to 2%, failing to identify the recurrent tumor. Therefore, p53 immunoreactivity, rather than Ki-67 nuclear stain, may be useful for identification of recurrent pituitary adenomas in childhood and adolescence.

Original languageEnglish
Pages (from-to)364-367
Number of pages4
JournalJournal of Child Neurology
Volume16
Issue number5
StatePublished - 2001

Fingerprint

Pituitary Neoplasms
Tumor Suppressor Genes
Recurrence
Genetic Suppression
Nuclear Antigens
Adenoma
Cell Cycle
Coloring Agents
Monoclonal Antibodies
Pediatrics
Mutation
Neoplasms

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Espay, A. J., Azzarelli, B., Williams, L., & Bodensteiner, J. B. (2001). Recurrence in pituitary adenomas in childhood and adolescence. Journal of Child Neurology, 16(5), 364-367.

Recurrence in pituitary adenomas in childhood and adolescence. / Espay, A. J.; Azzarelli, B.; Williams, Linda; Bodensteiner, J. B.

In: Journal of Child Neurology, Vol. 16, No. 5, 2001, p. 364-367.

Research output: Contribution to journalArticle

Espay, AJ, Azzarelli, B, Williams, L & Bodensteiner, JB 2001, 'Recurrence in pituitary adenomas in childhood and adolescence', Journal of Child Neurology, vol. 16, no. 5, pp. 364-367.
Espay, A. J. ; Azzarelli, B. ; Williams, Linda ; Bodensteiner, J. B. / Recurrence in pituitary adenomas in childhood and adolescence. In: Journal of Child Neurology. 2001 ; Vol. 16, No. 5. pp. 364-367.
@article{bce35e60f0b64fb29cae71d32a4c0bb5,
title = "Recurrence in pituitary adenomas in childhood and adolescence",
abstract = "Pediatric pituitary adenomas are thought to behave more aggressively than their adult counterparts, and the ability to predict the degree of such behavior remains elusive. Proliferation marker Ki-67 and tumor suppressor gene p53 mutations have been used in adults to assist in the evaluation of invasiveness and recurrence; however, their use in childhood and adolescence remains anecdotal. Our study evaluates the proliferative potential in pituitary adenomas of five patients and its relationship with recurrence or persistence of endocrinologic or clinical abnormalities. For such assessment, tissues were stained with monoclonal antibodies BP53-12 for p53 tumor suppressor gene mutation and MIB-1, which binds to cell cycle-specific nuclear antigen Ki-67. In our series, one patient with recurrent adenoma demonstrated the highest (50{\%}) p53 immunoreactivity. Ki-67-stained nuclei ranged from 0 to 2{\%}, failing to identify the recurrent tumor. Therefore, p53 immunoreactivity, rather than Ki-67 nuclear stain, may be useful for identification of recurrent pituitary adenomas in childhood and adolescence.",
author = "Espay, {A. J.} and B. Azzarelli and Linda Williams and Bodensteiner, {J. B.}",
year = "2001",
language = "English",
volume = "16",
pages = "364--367",
journal = "Journal of Child Neurology",
issn = "0883-0738",
publisher = "SAGE Publications Inc.",
number = "5",

}

TY - JOUR

T1 - Recurrence in pituitary adenomas in childhood and adolescence

AU - Espay, A. J.

AU - Azzarelli, B.

AU - Williams, Linda

AU - Bodensteiner, J. B.

PY - 2001

Y1 - 2001

N2 - Pediatric pituitary adenomas are thought to behave more aggressively than their adult counterparts, and the ability to predict the degree of such behavior remains elusive. Proliferation marker Ki-67 and tumor suppressor gene p53 mutations have been used in adults to assist in the evaluation of invasiveness and recurrence; however, their use in childhood and adolescence remains anecdotal. Our study evaluates the proliferative potential in pituitary adenomas of five patients and its relationship with recurrence or persistence of endocrinologic or clinical abnormalities. For such assessment, tissues were stained with monoclonal antibodies BP53-12 for p53 tumor suppressor gene mutation and MIB-1, which binds to cell cycle-specific nuclear antigen Ki-67. In our series, one patient with recurrent adenoma demonstrated the highest (50%) p53 immunoreactivity. Ki-67-stained nuclei ranged from 0 to 2%, failing to identify the recurrent tumor. Therefore, p53 immunoreactivity, rather than Ki-67 nuclear stain, may be useful for identification of recurrent pituitary adenomas in childhood and adolescence.

AB - Pediatric pituitary adenomas are thought to behave more aggressively than their adult counterparts, and the ability to predict the degree of such behavior remains elusive. Proliferation marker Ki-67 and tumor suppressor gene p53 mutations have been used in adults to assist in the evaluation of invasiveness and recurrence; however, their use in childhood and adolescence remains anecdotal. Our study evaluates the proliferative potential in pituitary adenomas of five patients and its relationship with recurrence or persistence of endocrinologic or clinical abnormalities. For such assessment, tissues were stained with monoclonal antibodies BP53-12 for p53 tumor suppressor gene mutation and MIB-1, which binds to cell cycle-specific nuclear antigen Ki-67. In our series, one patient with recurrent adenoma demonstrated the highest (50%) p53 immunoreactivity. Ki-67-stained nuclei ranged from 0 to 2%, failing to identify the recurrent tumor. Therefore, p53 immunoreactivity, rather than Ki-67 nuclear stain, may be useful for identification of recurrent pituitary adenomas in childhood and adolescence.

UR - http://www.scopus.com/inward/record.url?scp=0034975360&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034975360&partnerID=8YFLogxK

M3 - Article

C2 - 11392522

AN - SCOPUS:0034975360

VL - 16

SP - 364

EP - 367

JO - Journal of Child Neurology

JF - Journal of Child Neurology

SN - 0883-0738

IS - 5

ER -