Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis

Gregory A. Coté, Dhiraj Yadav, Judah A. Abberbock, David C. Whitcomb, Stuart Sherman, Bimaljit S. Sandhu, Michelle A. Anderson, Michele D. Lewis, Samer Alkaade, Vikesh K. Singh, John Baillie, Peter A. Banks, Darwin Conwell, Nalini M. Guda, Thiruvengadam Muniraj, Gong Tang, Randall Brand, Andres Gelrud, Stephen T. Amann, Christopher E. Forsmark & 3 others C. Mel Wilcox, Adam Slivka, Timothy B. Gardner

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: The impact of recurrent acute pancreatitis (RAP) on quality of life (QOL) is unknown. We hypothesized that RAP would reduce QOL even in the absence of chronic pancreatitis (CP). Methods: Data were pooled from three prospective, cross-sectional studies conducted across 27 U.S. centers (the North American Pancreatitis Studies); these included subjects with chronic pancreatitis (n = 1086), RAP alone (n = 508), and non-disease controls (n = 1025). QOL was measured using the Short Form 12 (SF-12), generating a Physical Component Summary (PCS) and the Mental Component Summary score (MCS). Multivariable regression models were developed to measure the effect of RAP on QOL, the predictors of lower QOL in those with RAP, and the differential effect QOL predictors between CP and RAP. Results: Compared to controls (51.0 ± 9.4), subjects with RAP (41.1 ± 11.4) and CP (37.2 ± 11.8) had lower PCS (p < 0.01). Subjects with CP had lower PCS compared to those with RAP (p < 0.01). Similarly, MCS was lower among RAP (44.6 ± 11.5) and CP (42.8 ± 12.2) subjects compared to controls (51.7 ± 9.1, p < 0.01). Subjects with CP had lower MCS compared to those with RAP (p < 0.01). After controlling for independent predictors of PCS, RAP was associated with lower PCS (estimate −8.46, p < 0.01) and MCS (estimate −6.45, p < 0.0001) compared to controls. The effect of endocrine insufficiency on PCS was differentially greater among RAP subjects (−1.28 for CP vs. −4.9 for RAP, p = 0.0184). Conclusions: Even in the absence of CP, subjects with RAP have lower physical and mental QOL. This underscores the importance of identifying interventions to attenuate RAP before the development of overt CP.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalAmerican Journal of Gastroenterology
DOIs
StateAccepted/In press - Jun 5 2018

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Chronic Pancreatitis
Pancreatitis
Quality of Life

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis. / Coté, Gregory A.; Yadav, Dhiraj; Abberbock, Judah A.; Whitcomb, David C.; Sherman, Stuart; Sandhu, Bimaljit S.; Anderson, Michelle A.; Lewis, Michele D.; Alkaade, Samer; Singh, Vikesh K.; Baillie, John; Banks, Peter A.; Conwell, Darwin; Guda, Nalini M.; Muniraj, Thiruvengadam; Tang, Gong; Brand, Randall; Gelrud, Andres; Amann, Stephen T.; Forsmark, Christopher E.; Wilcox, C. Mel; Slivka, Adam; Gardner, Timothy B.

In: American Journal of Gastroenterology, 05.06.2018, p. 1-7.

Research output: Contribution to journalArticle

Coté, GA, Yadav, D, Abberbock, JA, Whitcomb, DC, Sherman, S, Sandhu, BS, Anderson, MA, Lewis, MD, Alkaade, S, Singh, VK, Baillie, J, Banks, PA, Conwell, D, Guda, NM, Muniraj, T, Tang, G, Brand, R, Gelrud, A, Amann, ST, Forsmark, CE, Wilcox, CM, Slivka, A & Gardner, TB 2018, 'Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis', American Journal of Gastroenterology, pp. 1-7. https://doi.org/10.1038/s41395-018-0087-7
Coté, Gregory A. ; Yadav, Dhiraj ; Abberbock, Judah A. ; Whitcomb, David C. ; Sherman, Stuart ; Sandhu, Bimaljit S. ; Anderson, Michelle A. ; Lewis, Michele D. ; Alkaade, Samer ; Singh, Vikesh K. ; Baillie, John ; Banks, Peter A. ; Conwell, Darwin ; Guda, Nalini M. ; Muniraj, Thiruvengadam ; Tang, Gong ; Brand, Randall ; Gelrud, Andres ; Amann, Stephen T. ; Forsmark, Christopher E. ; Wilcox, C. Mel ; Slivka, Adam ; Gardner, Timothy B. / Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis. In: American Journal of Gastroenterology. 2018 ; pp. 1-7.
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title = "Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis",
abstract = "OBJECTIVES: The impact of recurrent acute pancreatitis (RAP) on quality of life (QOL) is unknown. We hypothesized that RAP would reduce QOL even in the absence of chronic pancreatitis (CP). Methods: Data were pooled from three prospective, cross-sectional studies conducted across 27 U.S. centers (the North American Pancreatitis Studies); these included subjects with chronic pancreatitis (n = 1086), RAP alone (n = 508), and non-disease controls (n = 1025). QOL was measured using the Short Form 12 (SF-12), generating a Physical Component Summary (PCS) and the Mental Component Summary score (MCS). Multivariable regression models were developed to measure the effect of RAP on QOL, the predictors of lower QOL in those with RAP, and the differential effect QOL predictors between CP and RAP. Results: Compared to controls (51.0 ± 9.4), subjects with RAP (41.1 ± 11.4) and CP (37.2 ± 11.8) had lower PCS (p < 0.01). Subjects with CP had lower PCS compared to those with RAP (p < 0.01). Similarly, MCS was lower among RAP (44.6 ± 11.5) and CP (42.8 ± 12.2) subjects compared to controls (51.7 ± 9.1, p < 0.01). Subjects with CP had lower MCS compared to those with RAP (p < 0.01). After controlling for independent predictors of PCS, RAP was associated with lower PCS (estimate −8.46, p < 0.01) and MCS (estimate −6.45, p < 0.0001) compared to controls. The effect of endocrine insufficiency on PCS was differentially greater among RAP subjects (−1.28 for CP vs. −4.9 for RAP, p = 0.0184). Conclusions: Even in the absence of CP, subjects with RAP have lower physical and mental QOL. This underscores the importance of identifying interventions to attenuate RAP before the development of overt CP.",
author = "Cot{\'e}, {Gregory A.} and Dhiraj Yadav and Abberbock, {Judah A.} and Whitcomb, {David C.} and Stuart Sherman and Sandhu, {Bimaljit S.} and Anderson, {Michelle A.} and Lewis, {Michele D.} and Samer Alkaade and Singh, {Vikesh K.} and John Baillie and Banks, {Peter A.} and Darwin Conwell and Guda, {Nalini M.} and Thiruvengadam Muniraj and Gong Tang and Randall Brand and Andres Gelrud and Amann, {Stephen T.} and Forsmark, {Christopher E.} and Wilcox, {C. Mel} and Adam Slivka and Gardner, {Timothy B.}",
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T1 - Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis

AU - Coté, Gregory A.

AU - Yadav, Dhiraj

AU - Abberbock, Judah A.

AU - Whitcomb, David C.

AU - Sherman, Stuart

AU - Sandhu, Bimaljit S.

AU - Anderson, Michelle A.

AU - Lewis, Michele D.

AU - Alkaade, Samer

AU - Singh, Vikesh K.

AU - Baillie, John

AU - Banks, Peter A.

AU - Conwell, Darwin

AU - Guda, Nalini M.

AU - Muniraj, Thiruvengadam

AU - Tang, Gong

AU - Brand, Randall

AU - Gelrud, Andres

AU - Amann, Stephen T.

AU - Forsmark, Christopher E.

AU - Wilcox, C. Mel

AU - Slivka, Adam

AU - Gardner, Timothy B.

PY - 2018/6/5

Y1 - 2018/6/5

N2 - OBJECTIVES: The impact of recurrent acute pancreatitis (RAP) on quality of life (QOL) is unknown. We hypothesized that RAP would reduce QOL even in the absence of chronic pancreatitis (CP). Methods: Data were pooled from three prospective, cross-sectional studies conducted across 27 U.S. centers (the North American Pancreatitis Studies); these included subjects with chronic pancreatitis (n = 1086), RAP alone (n = 508), and non-disease controls (n = 1025). QOL was measured using the Short Form 12 (SF-12), generating a Physical Component Summary (PCS) and the Mental Component Summary score (MCS). Multivariable regression models were developed to measure the effect of RAP on QOL, the predictors of lower QOL in those with RAP, and the differential effect QOL predictors between CP and RAP. Results: Compared to controls (51.0 ± 9.4), subjects with RAP (41.1 ± 11.4) and CP (37.2 ± 11.8) had lower PCS (p < 0.01). Subjects with CP had lower PCS compared to those with RAP (p < 0.01). Similarly, MCS was lower among RAP (44.6 ± 11.5) and CP (42.8 ± 12.2) subjects compared to controls (51.7 ± 9.1, p < 0.01). Subjects with CP had lower MCS compared to those with RAP (p < 0.01). After controlling for independent predictors of PCS, RAP was associated with lower PCS (estimate −8.46, p < 0.01) and MCS (estimate −6.45, p < 0.0001) compared to controls. The effect of endocrine insufficiency on PCS was differentially greater among RAP subjects (−1.28 for CP vs. −4.9 for RAP, p = 0.0184). Conclusions: Even in the absence of CP, subjects with RAP have lower physical and mental QOL. This underscores the importance of identifying interventions to attenuate RAP before the development of overt CP.

AB - OBJECTIVES: The impact of recurrent acute pancreatitis (RAP) on quality of life (QOL) is unknown. We hypothesized that RAP would reduce QOL even in the absence of chronic pancreatitis (CP). Methods: Data were pooled from three prospective, cross-sectional studies conducted across 27 U.S. centers (the North American Pancreatitis Studies); these included subjects with chronic pancreatitis (n = 1086), RAP alone (n = 508), and non-disease controls (n = 1025). QOL was measured using the Short Form 12 (SF-12), generating a Physical Component Summary (PCS) and the Mental Component Summary score (MCS). Multivariable regression models were developed to measure the effect of RAP on QOL, the predictors of lower QOL in those with RAP, and the differential effect QOL predictors between CP and RAP. Results: Compared to controls (51.0 ± 9.4), subjects with RAP (41.1 ± 11.4) and CP (37.2 ± 11.8) had lower PCS (p < 0.01). Subjects with CP had lower PCS compared to those with RAP (p < 0.01). Similarly, MCS was lower among RAP (44.6 ± 11.5) and CP (42.8 ± 12.2) subjects compared to controls (51.7 ± 9.1, p < 0.01). Subjects with CP had lower MCS compared to those with RAP (p < 0.01). After controlling for independent predictors of PCS, RAP was associated with lower PCS (estimate −8.46, p < 0.01) and MCS (estimate −6.45, p < 0.0001) compared to controls. The effect of endocrine insufficiency on PCS was differentially greater among RAP subjects (−1.28 for CP vs. −4.9 for RAP, p = 0.0184). Conclusions: Even in the absence of CP, subjects with RAP have lower physical and mental QOL. This underscores the importance of identifying interventions to attenuate RAP before the development of overt CP.

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