Redefining the Target Again: Chemotherapeutics as Vascular Disrupting Agents?

Research output: Contribution to journalShort survey

7 Scopus citations


In this issue of Cancer Cell, Shaked et al. (2008) provide novel mechanistic evidence that some chemotherapeutics induce circulating endothelial progenitor (CEP) mobilization with subsequent homing to tumor vasculature. Addition of an anti-VEGFR2 antibody increased antitumor activity only in combination with CEP-mobilizing chemotherapeutics. Here we discuss the implications of this work.

Original languageEnglish (US)
Pages (from-to)195-196
Number of pages2
JournalCancer Cell
Issue number3
StatePublished - Sep 9 2008


ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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