Redox metals and oxidative abnormalities in human prion diseases

Robert B. Petersen, Sandra L. Siedlak, Hyoung Gon Lee, Yong Sun Kim, Akihiko Nunomura, Fabrizio Tagliavini, Bernardino Ghetti, Patrick Cras, Paula I. Moreira, Rudy J. Castellani, Marin Guentchev, Herbert Budka, James W. Ironside, Pierluigi Gambetti, Mark A. Smith, George Perry

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54 Scopus citations

Abstract

Prion diseases are characterized by the accumulation of diffuse and aggregated plaques of protease-resistant prion protein (PrP) in the brains of affected individuals and animals. Whereas prion diseases in animals appear to be almost exclusively transmitted by infection, human prion diseases most often occur sporadically and, to a lesser extent, by inheritance or infection. In the sporadic cases (sporadic Creutzfeld-Jakob disease, sCJD), PrP-containing plaques are infrequent, whereas in transmitted (variant CJD) and inherited (Gerstmann-Straussler-Scheinker Syndrome) cases, plaques are a usual feature. In the current study, representative cases from each of the classes of human prion disease were analyzed for the presence of markers of oxidative damage that have been found in other neurodegenerative diseases. Interestingly, we found that the pattern of deposition of PrP, amyloid-β, and redox active metals was distinct for the various prion diseases. Whereas 8-hydroxyguanosine has been shown to be increased in sCJD, and inducible NOS is increased in scrapie-infected mice, well-studied markers of oxidative damage that accumulate in the lesions of other neurodegenerative diseases (such as Alzheimer's disease, progressive supranuclear palsy, and Parkinson's disease), such as heme oxygenase-1 and lipid peroxidation, were not found around PrP deposits or in vulnerable neurons. These findings suggest an important distinction in prion-related oxidative stress, indicating that different neurodegenerative pathways are involved in different prion diseases.

Original languageEnglish (US)
Pages (from-to)232-238
Number of pages7
JournalActa Neuropathologica
Volume110
Issue number3
DOIs
StatePublished - Sep 1 2005

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Keywords

  • Creutzfeld-Jakob disease
  • Gerstmann-Straussler-Scheinker syndrome
  • Oxidative damage
  • Prion
  • Redox metals

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Petersen, R. B., Siedlak, S. L., Lee, H. G., Kim, Y. S., Nunomura, A., Tagliavini, F., Ghetti, B., Cras, P., Moreira, P. I., Castellani, R. J., Guentchev, M., Budka, H., Ironside, J. W., Gambetti, P., Smith, M. A., & Perry, G. (2005). Redox metals and oxidative abnormalities in human prion diseases. Acta Neuropathologica, 110(3), 232-238. https://doi.org/10.1007/s00401-005-1034-4