Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression

Yanlin Jiang, Shaoyu Zhou, George Sandusky, Mark Kelley, Melissa Fishel

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Pancreatic cancer is a deadly disease that is virtually never cured. Understanding the chemoresistance intrinsic to this cancer will aid in developing new regimens. High expression of APE1/Ref-1, a DNA repair and redox signaling protein, is associated with resistance, poor outcome, and angiogenesis; little is known in pancreatic cancer. Immunostaining of adenocarcinoma shows greater APE1/Ref-1 expression than in normal pancreas tissue. A decrease in APE1/Ref-1 protein levels results in pancreatic cancer cell growth inhibition, increased apoptosis, and altered cell cycle progression. Endogenous cell cycle inhibitors increase when APE1/ Ref-1 is reduced, demonstrating its importance to proliferation and growth of pancreatic cancer.

Original languageEnglish
Pages (from-to)885-895
Number of pages11
JournalCancer Investigation
Volume28
Issue number9
DOIs
StatePublished - Oct 2010

Fingerprint

Pancreatic Neoplasms
DNA Repair
Oxidation-Reduction
Cell Survival
Cell Cycle
Cell Proliferation
Proteins
Growth
Pancreas
Adenocarcinoma
Apoptosis
Neoplasms

Keywords

  • APE1/Ref-1
  • cell cycle
  • Pancreatic cancer
  • siRNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

@article{8cc38a0cd85147db8b060feafbe538f1,
title = "Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression",
abstract = "Pancreatic cancer is a deadly disease that is virtually never cured. Understanding the chemoresistance intrinsic to this cancer will aid in developing new regimens. High expression of APE1/Ref-1, a DNA repair and redox signaling protein, is associated with resistance, poor outcome, and angiogenesis; little is known in pancreatic cancer. Immunostaining of adenocarcinoma shows greater APE1/Ref-1 expression than in normal pancreas tissue. A decrease in APE1/Ref-1 protein levels results in pancreatic cancer cell growth inhibition, increased apoptosis, and altered cell cycle progression. Endogenous cell cycle inhibitors increase when APE1/ Ref-1 is reduced, demonstrating its importance to proliferation and growth of pancreatic cancer.",
keywords = "APE1/Ref-1, cell cycle, Pancreatic cancer, siRNA",
author = "Yanlin Jiang and Shaoyu Zhou and George Sandusky and Mark Kelley and Melissa Fishel",
year = "2010",
month = "10",
doi = "10.3109/07357907.2010.512816",
language = "English",
volume = "28",
pages = "885--895",
journal = "Cancer Investigation",
issn = "0735-7907",
publisher = "Informa Healthcare",
number = "9",

}

TY - JOUR

T1 - Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression

AU - Jiang, Yanlin

AU - Zhou, Shaoyu

AU - Sandusky, George

AU - Kelley, Mark

AU - Fishel, Melissa

PY - 2010/10

Y1 - 2010/10

N2 - Pancreatic cancer is a deadly disease that is virtually never cured. Understanding the chemoresistance intrinsic to this cancer will aid in developing new regimens. High expression of APE1/Ref-1, a DNA repair and redox signaling protein, is associated with resistance, poor outcome, and angiogenesis; little is known in pancreatic cancer. Immunostaining of adenocarcinoma shows greater APE1/Ref-1 expression than in normal pancreas tissue. A decrease in APE1/Ref-1 protein levels results in pancreatic cancer cell growth inhibition, increased apoptosis, and altered cell cycle progression. Endogenous cell cycle inhibitors increase when APE1/ Ref-1 is reduced, demonstrating its importance to proliferation and growth of pancreatic cancer.

AB - Pancreatic cancer is a deadly disease that is virtually never cured. Understanding the chemoresistance intrinsic to this cancer will aid in developing new regimens. High expression of APE1/Ref-1, a DNA repair and redox signaling protein, is associated with resistance, poor outcome, and angiogenesis; little is known in pancreatic cancer. Immunostaining of adenocarcinoma shows greater APE1/Ref-1 expression than in normal pancreas tissue. A decrease in APE1/Ref-1 protein levels results in pancreatic cancer cell growth inhibition, increased apoptosis, and altered cell cycle progression. Endogenous cell cycle inhibitors increase when APE1/ Ref-1 is reduced, demonstrating its importance to proliferation and growth of pancreatic cancer.

KW - APE1/Ref-1

KW - cell cycle

KW - Pancreatic cancer

KW - siRNA

UR - http://www.scopus.com/inward/record.url?scp=77958001097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958001097&partnerID=8YFLogxK

U2 - 10.3109/07357907.2010.512816

DO - 10.3109/07357907.2010.512816

M3 - Article

VL - 28

SP - 885

EP - 895

JO - Cancer Investigation

JF - Cancer Investigation

SN - 0735-7907

IS - 9

ER -