Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression

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40 Scopus citations

Abstract

Pancreatic cancer is a deadly disease that is virtually never cured. Understanding the chemoresistance intrinsic to this cancer will aid in developing new regimens. High expression of APE1/Ref-1, a DNA repair and redox signaling protein, is associated with resistance, poor outcome, and angiogenesis; little is known in pancreatic cancer. Immunostaining of adenocarcinoma shows greater APE1/Ref-1 expression than in normal pancreas tissue. A decrease in APE1/Ref-1 protein levels results in pancreatic cancer cell growth inhibition, increased apoptosis, and altered cell cycle progression. Endogenous cell cycle inhibitors increase when APE1/ Ref-1 is reduced, demonstrating its importance to proliferation and growth of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)885-895
Number of pages11
JournalCancer Investigation
Volume28
Issue number9
DOIs
StatePublished - Oct 2010

Keywords

  • APE1/Ref-1
  • cell cycle
  • Pancreatic cancer
  • siRNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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