Reduced pericardial levels of endostatin correlate with collateral development in patients with ischemic heart disease

Vipul R. Panchal, Jalees Rehman, Anne T. Nguyen, John W. Brown, Mark W. Turrentine, Yousuf Mahomed, Keith L. March

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Objectives We investigated whether pericardial levels of a pro-angiogenic factor (vascular endothelial growth factor, VEGF) or an anti-angiogenic factor (endostatin) related to the presence of coronary collateral circulation in patients with significant coronary artery disease (CAD). Background Coronary collateralization favorably alters the prognosis of patients with occlusive CAD. The specific factors that mediate and maintain collateral formation in coronary vessel occlusion are yet to be identified. Methods Coronary angiograms from 39 patients undergoing coronary artery bypass surgery were evaluated for the absence of collaterals (n = 20) or the presence of Rentrop classification grade 3 collaterals (n = 19). Pericardial fluid samples were obtained at the time of surgery and were assayed for the VEGF and endostatin by enzyme-linked immunosorbent assay comparing the two groups of patients. Results Vascular endothelial growth factor levels were not significantly different between the groups (28.86 ± 4.67 pg/ml vs. 24.39 ± 3.08 pg/ml, p = 0.43). However, pericardial fluid endostatin levels were nearly 40% lower in patients with grade 3 collateralization compared with those lacking angiographic evidence of collaterals (15.17 ± 1.87 ng/ml vs. 24.25 ± 2.08 ng/ml, p < 0.0025). Conclusions Pericardial fluid levels of endostatin, but not VEGF, are associated with the presence or absence of collaterals in patients with CAD. These data suggest that the angiogenesis inhibitor endostatin levels may locally modulate coronary collateral formation.

Original languageEnglish (US)
Pages (from-to)1383-1387
Number of pages5
JournalJournal of the American College of Cardiology
Volume43
Issue number8
DOIs
StatePublished - Apr 21 2004

Keywords

  • CABG
  • CAD
  • Coronary artery bypass grafting
  • Coronary artery disease
  • Vascular endothelial growth factor
  • VEGF

ASJC Scopus subject areas

  • Nursing(all)

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