Plasma and CSF γ-aminobutyric acid (GABA) levels were determined in patients with affective illness and normal volunteers. Plasma GABA was significantly lower in the medication-free euthymic bipolar group (n = 23, p = 0.03) compared to normal volunteers (n = 36). Lithium-treated euthymic bipolar patients (n = 26) tended to have higher plasma GABA levels (p = 0.09) than the medication-free euthymic bipolar group. Plasma GABA in nine patients, measured in the euthymic state on and off lithium, was higher during lithium treatment (p < 0.02). In CSF, GABA was found to be significantly lower in a group of euthymic mediation-free unipolar and bipolar patients (n = 9) compared to normal volunteers (n = 39, p < 0.02) CSF GABA, on and off lithium in four bipolar patients, was significantly higher during lithium treatment (p < 0.02). This effect of lithium, increasing CSF and plasma GABA, may be related to its mechanism of therapeutic action.
|Original language||English (US)|
|Number of pages||10|
|State||Published - 1983|
ASJC Scopus subject areas
- Biological Psychiatry