EINGESCHRANKTE MYOKARDIALE FETTSAURE-UTILISATION BEI KORONARER HERZERKRANKUNG NACH SYMPTOMLIMITIERTER ERGOMETRISCHER BELASTUNG. NACHWEIS PATHOLOGISCHER STOFFWECHSELMUSTER MIT HILFE VON JOD-123-PHENYLPENTADEKANSAURE UND SEQUENTIELLER SPECT

Translated title of the contribution: Reduced regional cardiac free fatty acid utilization in coronary artery disease after symptom-limited exercise. Non-invasive assessment with I-123 phenylpentadecanoic acid and sequential single photon emission tomography

S. N. Reske, J. Nitsch, Elisabeth von der Lohe, H. J. Simon, P. Bardos, U. Bull

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Regional cardiac free fatty acid metabolism of 41 patients with coronary artery disease (CAD) and of 10 controls with normal coronary arteries was studied by means of I-123 phenylpentadecanoic acid (IPPA), a radioiodinated palmitic acid analog, and sequential single photon emission tomography (SPECT). All patients and controls underwent symptom - limited bicycle exercise, with the tracer being injected at peak stress. More than 99% of left ventricular segment of controls showed homogeneous tracer uptake and release, indicating homogeneous free fatty acid turnover in normal myocardium. Homogeneous postexercise uptake was followed by decreasing segmental activity in 75.1% of normally perfused segments in patients with CAD. Sixty-five percent and 88.6% of segments, assigned to the perfusion bed of 50%-75% and > 75% obstructed vessels had decreased IPPA release and/or reduced IPPA uptake. Patients with exercise induced ischemia had focal metabolic abnormalities in jeopardized myocardium for significantly longer time than clinical or electrocardiographic signs of ischemia (p <0.01). All patients with CAD and a negative stress test had metabolic abnormalities, but exhibited, compared to ECG - positive patients, less pronounced segmental metabolic aberrations. These findings indicate reduced cardiac utilization and delayed oxidation of IPPA, associated with exercise-induced ischemia in CAD. The metabolic changes suggest a marked sensitivity to ischemia as well as prolonged postischemic abnormalities of cardiac fatty acid metabolism in jeopardized myocardium.

Original languageGerman
Pages (from-to)262-270
Number of pages9
JournalZeitschrift fur Kardiologie
Volume78
Issue number4
StatePublished - 1989
Externally publishedYes

Fingerprint

Photons
Nonesterified Fatty Acids
Coronary Artery Disease
Tomography
Exercise
Acids
Ischemia
Myocardium
Palmitic Acid
Single-Photon Emission-Computed Tomography
Exercise Test
Coronary Vessels
Electrocardiography
Fatty Acids
Perfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "EINGESCHRANKTE MYOKARDIALE FETTSAURE-UTILISATION BEI KORONARER HERZERKRANKUNG NACH SYMPTOMLIMITIERTER ERGOMETRISCHER BELASTUNG. NACHWEIS PATHOLOGISCHER STOFFWECHSELMUSTER MIT HILFE VON JOD-123-PHENYLPENTADEKANSAURE UND SEQUENTIELLER SPECT",
abstract = "Regional cardiac free fatty acid metabolism of 41 patients with coronary artery disease (CAD) and of 10 controls with normal coronary arteries was studied by means of I-123 phenylpentadecanoic acid (IPPA), a radioiodinated palmitic acid analog, and sequential single photon emission tomography (SPECT). All patients and controls underwent symptom - limited bicycle exercise, with the tracer being injected at peak stress. More than 99{\%} of left ventricular segment of controls showed homogeneous tracer uptake and release, indicating homogeneous free fatty acid turnover in normal myocardium. Homogeneous postexercise uptake was followed by decreasing segmental activity in 75.1{\%} of normally perfused segments in patients with CAD. Sixty-five percent and 88.6{\%} of segments, assigned to the perfusion bed of 50{\%}-75{\%} and > 75{\%} obstructed vessels had decreased IPPA release and/or reduced IPPA uptake. Patients with exercise induced ischemia had focal metabolic abnormalities in jeopardized myocardium for significantly longer time than clinical or electrocardiographic signs of ischemia (p <0.01). All patients with CAD and a negative stress test had metabolic abnormalities, but exhibited, compared to ECG - positive patients, less pronounced segmental metabolic aberrations. These findings indicate reduced cardiac utilization and delayed oxidation of IPPA, associated with exercise-induced ischemia in CAD. The metabolic changes suggest a marked sensitivity to ischemia as well as prolonged postischemic abnormalities of cardiac fatty acid metabolism in jeopardized myocardium.",
author = "Reske, {S. N.} and J. Nitsch and {von der Lohe}, Elisabeth and Simon, {H. J.} and P. Bardos and U. Bull",
year = "1989",
language = "German",
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AU - Reske, S. N.

AU - Nitsch, J.

AU - von der Lohe, Elisabeth

AU - Simon, H. J.

AU - Bardos, P.

AU - Bull, U.

PY - 1989

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N2 - Regional cardiac free fatty acid metabolism of 41 patients with coronary artery disease (CAD) and of 10 controls with normal coronary arteries was studied by means of I-123 phenylpentadecanoic acid (IPPA), a radioiodinated palmitic acid analog, and sequential single photon emission tomography (SPECT). All patients and controls underwent symptom - limited bicycle exercise, with the tracer being injected at peak stress. More than 99% of left ventricular segment of controls showed homogeneous tracer uptake and release, indicating homogeneous free fatty acid turnover in normal myocardium. Homogeneous postexercise uptake was followed by decreasing segmental activity in 75.1% of normally perfused segments in patients with CAD. Sixty-five percent and 88.6% of segments, assigned to the perfusion bed of 50%-75% and > 75% obstructed vessels had decreased IPPA release and/or reduced IPPA uptake. Patients with exercise induced ischemia had focal metabolic abnormalities in jeopardized myocardium for significantly longer time than clinical or electrocardiographic signs of ischemia (p <0.01). All patients with CAD and a negative stress test had metabolic abnormalities, but exhibited, compared to ECG - positive patients, less pronounced segmental metabolic aberrations. These findings indicate reduced cardiac utilization and delayed oxidation of IPPA, associated with exercise-induced ischemia in CAD. The metabolic changes suggest a marked sensitivity to ischemia as well as prolonged postischemic abnormalities of cardiac fatty acid metabolism in jeopardized myocardium.

AB - Regional cardiac free fatty acid metabolism of 41 patients with coronary artery disease (CAD) and of 10 controls with normal coronary arteries was studied by means of I-123 phenylpentadecanoic acid (IPPA), a radioiodinated palmitic acid analog, and sequential single photon emission tomography (SPECT). All patients and controls underwent symptom - limited bicycle exercise, with the tracer being injected at peak stress. More than 99% of left ventricular segment of controls showed homogeneous tracer uptake and release, indicating homogeneous free fatty acid turnover in normal myocardium. Homogeneous postexercise uptake was followed by decreasing segmental activity in 75.1% of normally perfused segments in patients with CAD. Sixty-five percent and 88.6% of segments, assigned to the perfusion bed of 50%-75% and > 75% obstructed vessels had decreased IPPA release and/or reduced IPPA uptake. Patients with exercise induced ischemia had focal metabolic abnormalities in jeopardized myocardium for significantly longer time than clinical or electrocardiographic signs of ischemia (p <0.01). All patients with CAD and a negative stress test had metabolic abnormalities, but exhibited, compared to ECG - positive patients, less pronounced segmental metabolic aberrations. These findings indicate reduced cardiac utilization and delayed oxidation of IPPA, associated with exercise-induced ischemia in CAD. The metabolic changes suggest a marked sensitivity to ischemia as well as prolonged postischemic abnormalities of cardiac fatty acid metabolism in jeopardized myocardium.

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