Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection

Yinling Lin, Tonya J. Roberts, Philip M. Spence, Randy Brutkiewicz

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Mice were infected with lymphocytic choriomeningitis virus (LCMV) to determine if changes in CD1d expression occurred during an acute virus infection. It is interesting that a decrease in CD1d expression on splenic dendritic cells (DC) and macrophages (MΦ) was observed for at least 3 months post-LCMV infection, and vaccinia virus and vesicular stomatitis virus induced similar changes in CD1d upon infection with those viruses. The reduction of CD1d cell-surface expression on DC and MΦ was independent of interferon-γ and interleukin-12 expression but partially recovered in transporter associated with antigen processing-1-deficient mice, suggesting that CD8+ T cells may play a role. Thus, one consequence of the induction of a cellular immune response is a change in CD1d expression, which may constitute a key element in regulating antiviral immunity.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalJournal of Leukocyte Biology
Volume77
Issue number2
DOIs
StatePublished - Feb 2005

Fingerprint

Lymphocytic choriomeningitis virus
Virus Diseases
Dendritic Cells
Macrophages
Viruses
Vesicular Stomatitis
Vaccinia virus
Antigen Presentation
Interleukin-12
Cellular Immunity
Interferons
Antiviral Agents
Immunity
T-Lymphocytes
Infection

Keywords

  • Antigen presenting cells
  • Innate immunity
  • Peripheral organs
  • Spleen

ASJC Scopus subject areas

  • Cell Biology

Cite this

Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection. / Lin, Yinling; Roberts, Tonya J.; Spence, Philip M.; Brutkiewicz, Randy.

In: Journal of Leukocyte Biology, Vol. 77, No. 2, 02.2005, p. 151-158.

Research output: Contribution to journalArticle

Lin, Yinling ; Roberts, Tonya J. ; Spence, Philip M. ; Brutkiewicz, Randy. / Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection. In: Journal of Leukocyte Biology. 2005 ; Vol. 77, No. 2. pp. 151-158.
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