Reduction in false-positive aspergillus serum galactomannan enzyme immunoassay results associated with use of piperacillin-tazobactam in the United States

Paschalis Vergidis; Raymund R. Razonable; L. Joseph Wheat; Lynn Estes; Angela M. Caliendo; Lindsey R. Baden; John R. Wingard; John Baddley; Maha Assi; Steven Norris; Pranatharthi Chandrasekar; Ryan Shields; Hong Nguyen; Alison Freifeld; Richard Kohler; Martin Kleiman; Thomas J. Walsh; Chadi A. Hage

doi:10.1128/JCM.00285-14

Reduction in false-positive aspergillus serum galactomannan enzyme immunoassay results associated with use of piperacillin-tazobactam in the United States

Paschalis Vergidis, Raymund R. Razonable, L. Joseph Wheat, Lynn Estes, Angela M. Caliendo, Lindsey R. Baden, John R. Wingard, John Baddley, Maha Assi, Steven Norris, Pranatharthi Chandrasekar, Ryan Shields, Hong Nguyen, Alison Freifeld, Richard Kohler, Martin Kleiman, Thomas J. Walsh, Chadi A. Hage

Pulmonary & Critical Care Medicine

Research output: Contribution to journal › Article

34 Scopus citations

Abstract

Piperacillin-tazobactam (PTZ) is known to cause false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA), due to contamination with galactomannan (GM). We tested 32 lots of PTZ and 27 serum specimens from patients receiving PTZ. GM was not detected in the lots of PTZ; one serum specimen (3.7%) wa.

Original language	English (US)
Pages (from-to)	2199-2201
Number of pages	3
Journal	Journal of clinical microbiology
Volume	52
Issue number	6
DOIs	https://doi.org/10.1128/JCM.00285-14
State	Published - Jun 2014

ASJC Scopus subject areas

Microbiology (medical)

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10.1128/JCM.00285-14

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Vergidis, P., Razonable, R. R., Wheat, L. J., Estes, L., Caliendo, A. M., Baden, L. R., Wingard, J. R., Baddley, J., Assi, M., Norris, S., Chandrasekar, P., Shields, R., Nguyen, H., Freifeld, A., Kohler, R., Kleiman, M., Walsh, T. J., & Hage, C. A. (2014). Reduction in false-positive aspergillus serum galactomannan enzyme immunoassay results associated with use of piperacillin-tazobactam in the United States. Journal of clinical microbiology, 52(6), 2199-2201. https://doi.org/10.1128/JCM.00285-14

Reduction in false-positive aspergillus serum galactomannan enzyme immunoassay results associated with use of piperacillin-tazobactam in the United States. / Vergidis, Paschalis; Razonable, Raymund R.; Wheat, L. Joseph; Estes, Lynn; Caliendo, Angela M.; Baden, Lindsey R.; Wingard, John R.; Baddley, John; Assi, Maha; Norris, Steven; Chandrasekar, Pranatharthi; Shields, Ryan; Nguyen, Hong; Freifeld, Alison; Kohler, Richard; Kleiman, Martin; Walsh, Thomas J.; Hage, Chadi A.

In: Journal of clinical microbiology, Vol. 52, No. 6, 06.2014, p. 2199-2201.

Research output: Contribution to journal › Article

Vergidis, P, Razonable, RR, Wheat, LJ, Estes, L, Caliendo, AM, Baden, LR, Wingard, JR, Baddley, J, Assi, M, Norris, S, Chandrasekar, P, Shields, R, Nguyen, H, Freifeld, A, Kohler, R, Kleiman, M, Walsh, TJ & Hage, CA 2014, 'Reduction in false-positive aspergillus serum galactomannan enzyme immunoassay results associated with use of piperacillin-tazobactam in the United States', Journal of clinical microbiology, vol. 52, no. 6, pp. 2199-2201. https://doi.org/10.1128/JCM.00285-14

Vergidis, Paschalis ; Razonable, Raymund R. ; Wheat, L. Joseph ; Estes, Lynn ; Caliendo, Angela M. ; Baden, Lindsey R. ; Wingard, John R. ; Baddley, John ; Assi, Maha ; Norris, Steven ; Chandrasekar, Pranatharthi ; Shields, Ryan ; Nguyen, Hong ; Freifeld, Alison ; Kohler, Richard ; Kleiman, Martin ; Walsh, Thomas J. ; Hage, Chadi A. / Reduction in false-positive aspergillus serum galactomannan enzyme immunoassay results associated with use of piperacillin-tazobactam in the United States. In: Journal of clinical microbiology. 2014 ; Vol. 52, No. 6. pp. 2199-2201.

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abstract = "Piperacillin-tazobactam (PTZ) is known to cause false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA), due to contamination with galactomannan (GM). We tested 32 lots of PTZ and 27 serum specimens from patients receiving PTZ. GM was not detected in the lots of PTZ; one serum specimen (3.7%) wa.",

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AU - Estes, Lynn

AU - Caliendo, Angela M.

AU - Baden, Lindsey R.

AU - Wingard, John R.

AU - Baddley, John

AU - Assi, Maha

AU - Norris, Steven

AU - Chandrasekar, Pranatharthi

AU - Shields, Ryan

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AU - Freifeld, Alison

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