Reduction in Overt and Silent Stroke Recurrence Rate Following Cerebral Revascularization Surgery in Children with Sickle Cell Disease and Severe Cerebral Vasculopathy

Erin M. Hall, Jeffrey Leonard, Jodi Smith, Kristin P. Guilliams, Michael Binkley, Robert Fallon, Monica L. Hulbert

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Children with sickle cell disease (SCD) and moyamoya may benefit from indirect cerebral revascularization surgery in addition to chronic blood transfusion therapy for infarct prevention. We sought to compare overt and silent infarct recurrence rates in children with SCD undergoing revascularization. Methods: This was a retrospective cohort study of all children with SCD and moyamoya treated at two children's hospitals. Clinical events and imaging studies were reviewed. Results: Twenty-seven children with SCD and confirmed moyamoya receiving chronic transfusion therapy were identified, of whom 12 underwent indirect cerebral revascularization. Two subjects had postoperative transient ischemic attacks and another had a subarachnoid blood collection, none of which caused permanent consequences. Two subjects had surgical wound infections. Among these 12 children, the rate of overt and silent infarct recurrence decreased from 13.4 infarcts/100 patient-years before revascularization to 0 infarcts/100 patient-years after revascularization (P = 0.0057); the postrevascularization infarct recurrence rate was also significantly lower than the overall infarct recurrence of 8.87 infarcts/100 patient-years in 15 children without cerebral revascularization (P = 0.025). Conclusions: The rate of overt and silent infarct recurrence was significantly lower following indirect cerebral revascularization. A prospective study of cerebral revascularization in children with SCD is needed.

Original languageEnglish (US)
Pages (from-to)1431-1437
Number of pages7
JournalPediatric Blood and Cancer
Volume63
Issue number8
DOIs
StatePublished - Aug 1 2016

Fingerprint

Cerebral Revascularization
Sickle Cell Anemia
Stroke
Recurrence
Surgical Wound Infection
Transient Ischemic Attack
Blood Transfusion
Cohort Studies
Retrospective Studies
Prospective Studies

Keywords

  • cerebral vasculopathy
  • moyamoya
  • pediatric
  • sickle cell anemia
  • stroke

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)
  • Hematology
  • Oncology

Cite this

Reduction in Overt and Silent Stroke Recurrence Rate Following Cerebral Revascularization Surgery in Children with Sickle Cell Disease and Severe Cerebral Vasculopathy. / Hall, Erin M.; Leonard, Jeffrey; Smith, Jodi; Guilliams, Kristin P.; Binkley, Michael; Fallon, Robert; Hulbert, Monica L.

In: Pediatric Blood and Cancer, Vol. 63, No. 8, 01.08.2016, p. 1431-1437.

Research output: Contribution to journalArticle

Hall, Erin M. ; Leonard, Jeffrey ; Smith, Jodi ; Guilliams, Kristin P. ; Binkley, Michael ; Fallon, Robert ; Hulbert, Monica L. / Reduction in Overt and Silent Stroke Recurrence Rate Following Cerebral Revascularization Surgery in Children with Sickle Cell Disease and Severe Cerebral Vasculopathy. In: Pediatric Blood and Cancer. 2016 ; Vol. 63, No. 8. pp. 1431-1437.
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AB - Background: Children with sickle cell disease (SCD) and moyamoya may benefit from indirect cerebral revascularization surgery in addition to chronic blood transfusion therapy for infarct prevention. We sought to compare overt and silent infarct recurrence rates in children with SCD undergoing revascularization. Methods: This was a retrospective cohort study of all children with SCD and moyamoya treated at two children's hospitals. Clinical events and imaging studies were reviewed. Results: Twenty-seven children with SCD and confirmed moyamoya receiving chronic transfusion therapy were identified, of whom 12 underwent indirect cerebral revascularization. Two subjects had postoperative transient ischemic attacks and another had a subarachnoid blood collection, none of which caused permanent consequences. Two subjects had surgical wound infections. Among these 12 children, the rate of overt and silent infarct recurrence decreased from 13.4 infarcts/100 patient-years before revascularization to 0 infarcts/100 patient-years after revascularization (P = 0.0057); the postrevascularization infarct recurrence rate was also significantly lower than the overall infarct recurrence of 8.87 infarcts/100 patient-years in 15 children without cerebral revascularization (P = 0.025). Conclusions: The rate of overt and silent infarct recurrence was significantly lower following indirect cerebral revascularization. A prospective study of cerebral revascularization in children with SCD is needed.

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