Reduction of cerebellar volume in major depression

A controlled MRI study

P. Rodrigo Escalona, Bridget Early, William M. McDonald, P. Murali Doraiswamy, Sunjay A. Shah, Mustafa M. Husain, Orest Boyko, Gary S. Figiel, Everett H. Ellinwood, Charles B. Nemeroff, K. Ranga R. Krishnan

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A systematic sampling stereological method of serially acquired axial intermediate T2‐weighted Spin echo magnetic resonance imaging (MRI) of the brain was used to measure cerebellar volume in 30 patients who fulfilled DSM III criteria for major depression and compared with 35 normal controls. The mean cerebellar volume of depressed patients was significantly smaller than the controls. This preliminary study adds new evidence for the possible participation of the cerebellum in the pathophysiology of major depression and warrants further investigation in this area. Depression 1:156–158 (1993). © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)156-158
Number of pages3
JournalDepression
Volume1
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Magnetic Resonance Imaging
Diagnostic and Statistical Manual of Mental Disorders
Cerebellum
Brain

Keywords

  • cerebellum
  • magnetic resonance imaging
  • major depression

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Escalona, P. R., Early, B., McDonald, W. M., Doraiswamy, P. M., Shah, S. A., Husain, M. M., ... Krishnan, K. R. R. (1993). Reduction of cerebellar volume in major depression: A controlled MRI study. Depression, 1(3), 156-158. https://doi.org/10.1002/depr.3050010307

Reduction of cerebellar volume in major depression : A controlled MRI study. / Escalona, P. Rodrigo; Early, Bridget; McDonald, William M.; Doraiswamy, P. Murali; Shah, Sunjay A.; Husain, Mustafa M.; Boyko, Orest; Figiel, Gary S.; Ellinwood, Everett H.; Nemeroff, Charles B.; Krishnan, K. Ranga R.

In: Depression, Vol. 1, No. 3, 1993, p. 156-158.

Research output: Contribution to journalArticle

Escalona, PR, Early, B, McDonald, WM, Doraiswamy, PM, Shah, SA, Husain, MM, Boyko, O, Figiel, GS, Ellinwood, EH, Nemeroff, CB & Krishnan, KRR 1993, 'Reduction of cerebellar volume in major depression: A controlled MRI study', Depression, vol. 1, no. 3, pp. 156-158. https://doi.org/10.1002/depr.3050010307
Escalona PR, Early B, McDonald WM, Doraiswamy PM, Shah SA, Husain MM et al. Reduction of cerebellar volume in major depression: A controlled MRI study. Depression. 1993;1(3):156-158. https://doi.org/10.1002/depr.3050010307
Escalona, P. Rodrigo ; Early, Bridget ; McDonald, William M. ; Doraiswamy, P. Murali ; Shah, Sunjay A. ; Husain, Mustafa M. ; Boyko, Orest ; Figiel, Gary S. ; Ellinwood, Everett H. ; Nemeroff, Charles B. ; Krishnan, K. Ranga R. / Reduction of cerebellar volume in major depression : A controlled MRI study. In: Depression. 1993 ; Vol. 1, No. 3. pp. 156-158.
@article{ea0db7fdaedc4b3a9e13b65d6aa68622,
title = "Reduction of cerebellar volume in major depression: A controlled MRI study",
abstract = "A systematic sampling stereological method of serially acquired axial intermediate T2‐weighted Spin echo magnetic resonance imaging (MRI) of the brain was used to measure cerebellar volume in 30 patients who fulfilled DSM III criteria for major depression and compared with 35 normal controls. The mean cerebellar volume of depressed patients was significantly smaller than the controls. This preliminary study adds new evidence for the possible participation of the cerebellum in the pathophysiology of major depression and warrants further investigation in this area. Depression 1:156–158 (1993). {\circledC} 1993 Wiley‐Liss, Inc.",
keywords = "cerebellum, magnetic resonance imaging, major depression",
author = "Escalona, {P. Rodrigo} and Bridget Early and McDonald, {William M.} and Doraiswamy, {P. Murali} and Shah, {Sunjay A.} and Husain, {Mustafa M.} and Orest Boyko and Figiel, {Gary S.} and Ellinwood, {Everett H.} and Nemeroff, {Charles B.} and Krishnan, {K. Ranga R.}",
year = "1993",
doi = "10.1002/depr.3050010307",
language = "English (US)",
volume = "1",
pages = "156--158",
journal = "Depression",
issn = "1062-6417",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Reduction of cerebellar volume in major depression

T2 - A controlled MRI study

AU - Escalona, P. Rodrigo

AU - Early, Bridget

AU - McDonald, William M.

AU - Doraiswamy, P. Murali

AU - Shah, Sunjay A.

AU - Husain, Mustafa M.

AU - Boyko, Orest

AU - Figiel, Gary S.

AU - Ellinwood, Everett H.

AU - Nemeroff, Charles B.

AU - Krishnan, K. Ranga R.

PY - 1993

Y1 - 1993

N2 - A systematic sampling stereological method of serially acquired axial intermediate T2‐weighted Spin echo magnetic resonance imaging (MRI) of the brain was used to measure cerebellar volume in 30 patients who fulfilled DSM III criteria for major depression and compared with 35 normal controls. The mean cerebellar volume of depressed patients was significantly smaller than the controls. This preliminary study adds new evidence for the possible participation of the cerebellum in the pathophysiology of major depression and warrants further investigation in this area. Depression 1:156–158 (1993). © 1993 Wiley‐Liss, Inc.

AB - A systematic sampling stereological method of serially acquired axial intermediate T2‐weighted Spin echo magnetic resonance imaging (MRI) of the brain was used to measure cerebellar volume in 30 patients who fulfilled DSM III criteria for major depression and compared with 35 normal controls. The mean cerebellar volume of depressed patients was significantly smaller than the controls. This preliminary study adds new evidence for the possible participation of the cerebellum in the pathophysiology of major depression and warrants further investigation in this area. Depression 1:156–158 (1993). © 1993 Wiley‐Liss, Inc.

KW - cerebellum

KW - magnetic resonance imaging

KW - major depression

UR - http://www.scopus.com/inward/record.url?scp=85005299883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85005299883&partnerID=8YFLogxK

U2 - 10.1002/depr.3050010307

DO - 10.1002/depr.3050010307

M3 - Article

VL - 1

SP - 156

EP - 158

JO - Depression

JF - Depression

SN - 1062-6417

IS - 3

ER -