Reduction of FHIT gene expression in primary lung cancer

Yun Wang, Qinghua Zhou, Shangfu Zhang, Liang Cheng, Lunxu Liu, Lu Li, Zhu Wu, Guowei Che, Jianjun Qin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To investigate the role of FHIT (fragile histidine triad) gene in oncogenesis and progression of human lung cancer. Methods: The expression of FHIT gene was detected in 166 lung cancer samples and 37 benign pulmonary lesion tissues as control by immunohistochemistry. Results: The positive rate of FHIT expression in lung cancer tissues was 63.03% ± 26.41%, which was significantly lower than that in tisssues adjacent to cancer (83.74% ± 17.46%) (P <0.01), and both positive rates in cancer tissues and tissues adjacent to cancer were significantly lower than that in benign lesion tissues (92.98 ± 5.56%) (P <0.01). The expression level of FHIT gene was closely related to histological classification, cancer cell differentiation, P-TNM stages and lymph node involvement in lung cancer patients (P <0.05). The positive rate of FHIT expression in smoking lung cancer patients was remarkably lower than that in non-smoking ones (55.14% ± 27.55% vs 71.93% ± 22.05%, P <0.01). The postoperative survival time in patients with high FHIT expression was significantly longer than those with low expression (P <0.05). Conclusion: Reduction of FHIT gene expression might be associated with the oncogenesis and progression of human lung cancer; Smoking may be one of the important reasons of reduction of FHIT gene expression in lung cancer patients.

Original languageEnglish (US)
Pages (from-to)6-9
Number of pages4
JournalChinese Journal of Lung Cancer
Volume5
Issue number1
StatePublished - Feb 2002
Externally publishedYes

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Histidine
Lung Neoplasms
Gene Expression
Neoplasms
Carcinogenesis
Smoking
Genes
Cell Differentiation
Lymph Nodes
Immunohistochemistry
Lung
Survival

Keywords

  • FHIT gene
  • Immunohistochemistry
  • Lung neoplasms

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Wang, Y., Zhou, Q., Zhang, S., Cheng, L., Liu, L., Li, L., ... Qin, J. (2002). Reduction of FHIT gene expression in primary lung cancer. Chinese Journal of Lung Cancer, 5(1), 6-9.

Reduction of FHIT gene expression in primary lung cancer. / Wang, Yun; Zhou, Qinghua; Zhang, Shangfu; Cheng, Liang; Liu, Lunxu; Li, Lu; Wu, Zhu; Che, Guowei; Qin, Jianjun.

In: Chinese Journal of Lung Cancer, Vol. 5, No. 1, 02.2002, p. 6-9.

Research output: Contribution to journalArticle

Wang, Y, Zhou, Q, Zhang, S, Cheng, L, Liu, L, Li, L, Wu, Z, Che, G & Qin, J 2002, 'Reduction of FHIT gene expression in primary lung cancer', Chinese Journal of Lung Cancer, vol. 5, no. 1, pp. 6-9.
Wang Y, Zhou Q, Zhang S, Cheng L, Liu L, Li L et al. Reduction of FHIT gene expression in primary lung cancer. Chinese Journal of Lung Cancer. 2002 Feb;5(1):6-9.
Wang, Yun ; Zhou, Qinghua ; Zhang, Shangfu ; Cheng, Liang ; Liu, Lunxu ; Li, Lu ; Wu, Zhu ; Che, Guowei ; Qin, Jianjun. / Reduction of FHIT gene expression in primary lung cancer. In: Chinese Journal of Lung Cancer. 2002 ; Vol. 5, No. 1. pp. 6-9.
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