Reduction of FHIT gene expression in primary lung cancer

Yun Wang, Qinghua Zhou, Shangfu Zhang, Liang Cheng, Lunxu Liu, Lu Li, Zhu Wu, Guowei Che, Jianjun Qin

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objective: To investigate the role of FHIT (fragile histidine triad) gene in oncogenesis and progression of human lung cancer. Methods: The expression of FHIT gene was detected in 166 lung cancer samples and 37 benign pulmonary lesion tissues as control by immunohistochemistry. Results: The positive rate of FHIT expression in lung cancer tissues was 63.03% ± 26.41%, which was significantly lower than that in tisssues adjacent to cancer (83.74% ± 17.46%) (P < 0.01), and both positive rates in cancer tissues and tissues adjacent to cancer were significantly lower than that in benign lesion tissues (92.98 ± 5.56%) (P < 0.01). The expression level of FHIT gene was closely related to histological classification, cancer cell differentiation, P-TNM stages and lymph node involvement in lung cancer patients (P < 0.05). The positive rate of FHIT expression in smoking lung cancer patients was remarkably lower than that in non-smoking ones (55.14% ± 27.55% vs 71.93% ± 22.05%, P < 0.01). The postoperative survival time in patients with high FHIT expression was significantly longer than those with low expression (P < 0.05). Conclusion: Reduction of FHIT gene expression might be associated with the oncogenesis and progression of human lung cancer; Smoking may be one of the important reasons of reduction of FHIT gene expression in lung cancer patients.

Original languageEnglish (US)
Pages (from-to)6-9
Number of pages4
JournalChinese Journal of Lung Cancer
Volume5
Issue number1
StatePublished - Feb 1 2002
Externally publishedYes

Keywords

  • FHIT gene
  • Immunohistochemistry
  • Lung neoplasms

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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  • Cite this

    Wang, Y., Zhou, Q., Zhang, S., Cheng, L., Liu, L., Li, L., Wu, Z., Che, G., & Qin, J. (2002). Reduction of FHIT gene expression in primary lung cancer. Chinese Journal of Lung Cancer, 5(1), 6-9.