Reduction of stress-induced analgesia following ethanol exposure in mice

Richard Bell, R. Denis Soignier, Richard D. Olson, Anthony L. Vaccarino

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In the present study, we examined the effects of ethanol treatment on the subsequent expression of opioid and nonopioid forms of swim stress- induced analgesia (SSIA). In Experiment 1, mice were injected with ethanol (2.5 g/kg, IP) or an equal volume of saline once a day for two days. Animals received no treatment on day 3. On day 4, the animals were tested for opioid (3-min swim in water maintained at 32°C) or nonopioid (3-min swim in water maintained at 20°C) SSIA in the hotplate test (52°C). Mice pretreated with ethanol injections showed a decrease in nonopioid SSIA, but not in opioid SSIA. In Experiment 2, mice were given an ethanol solution (10%) or tap water to drink for 15 days. On day 16, all animals were given tap water to drink. On day 17, the animals were tested for opioid or nonopioid SSIA. Neither form of SSIA was modified in mice that drank the ethanol solution. These results show that ethanol pretreatment can modify nonopioid endogenous analgesic responses in mice. Further, the route of administration influences the effects of ethanol pretreatment on SSIA.

Original languageEnglish (US)
Pages (from-to)731-736
Number of pages6
JournalLife Sciences
Volume63
Issue number9
DOIs
StatePublished - Aug 24 1998
Externally publishedYes

Fingerprint

Analgesia
Ethanol
Opioid Analgesics
Animals
Water
Non-Narcotic Analgesics
Analgesics
Experiments
Injections
Therapeutics

Keywords

  • Cross- tolerance
  • Ethanol
  • Hot plate test
  • Mice
  • Nonopioid
  • Opioid
  • Pain
  • Swim stress-induced analgesia

ASJC Scopus subject areas

  • Pharmacology

Cite this

Reduction of stress-induced analgesia following ethanol exposure in mice. / Bell, Richard; Soignier, R. Denis; Olson, Richard D.; Vaccarino, Anthony L.

In: Life Sciences, Vol. 63, No. 9, 24.08.1998, p. 731-736.

Research output: Contribution to journalArticle

Bell, Richard ; Soignier, R. Denis ; Olson, Richard D. ; Vaccarino, Anthony L. / Reduction of stress-induced analgesia following ethanol exposure in mice. In: Life Sciences. 1998 ; Vol. 63, No. 9. pp. 731-736.
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