Reductions in retrobulbar and retinal capillary blood flow strongly correlate with changes in optic nerve head and retinal morphology over 4 years in open-angle glaucoma patients of African descent compared with patients of European descent

Brent Siesky, Alon Harris, Joseph Carr, Alice Verticchio Vercellin, Rehan M. Hussain, Priyanka Parekh Hembree, Scott Wentz, Michael Isaacs, George Eckert, Nicholas A. Moore

Research output: Contribution to journalArticle

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Abstract

Purpose: To investigate the relationship of changes in ocular blood flow with optic nerve head (ONH) and retinal morphology in openangle glaucoma (OAG) patients of African versus European descent (ED) over 4 years. Materials and Methods: In this study, 112 patients with OAG were examined at baseline, 79 [59 ED, 20 African descent (AD)] of which were followed for 4 years. Retinal capillary blood flow was assessed with Heidelberg retinal flowmetry. Retrobulbar blood flow was measured by color Doppler imaging. Retinal structural changes were examined with optical coherence tomography and Heidelberg retinal tomography-III. Mixed-model analysis of covariance was used to test for the significance of change from baseline to 4-year follow-up, and Pearson correlation coefficients were calculated to evaluate linear associations. Results: In OAG patients of AD, structural changes of the ONH demonstrated a strong association with the end diastolic velocities and resistive indices of the short posterior ciliary arteries over 4 years. In addition, there was a significantly larger increase in the avascular area of the inferior retina in patients of AD, and this reduction in retinal capillaries strongly correlated with a reduction in macular thickness. Conclusions: Reductions in retinal capillary and retrobulbar blood flow strongly correlated with changes in the ONH and macular thickness over 4 years in OAG patients of AD compared with ED. These data suggest that ocular vascular health may be a more influential contributing factor in the pathophysiology of OAG in patients of AD compared with ED.

Original languageEnglish (US)
Pages (from-to)750-757
Number of pages8
JournalJournal of Glaucoma
Volume25
Issue number9
DOIs
StatePublished - 2016

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Open Angle Glaucoma
Optic Disk
Glaucoma
Ciliary Arteries
Rheology
Optical Coherence Tomography
Blood Vessels
Retina
Color
Tomography
Health

Keywords

  • Blood flow
  • Open-angle glaucoma
  • Optic nerve head
  • Race
  • Retina

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Reductions in retrobulbar and retinal capillary blood flow strongly correlate with changes in optic nerve head and retinal morphology over 4 years in open-angle glaucoma patients of African descent compared with patients of European descent. / Siesky, Brent; Harris, Alon; Carr, Joseph; Vercellin, Alice Verticchio; Hussain, Rehan M.; Hembree, Priyanka Parekh; Wentz, Scott; Isaacs, Michael; Eckert, George; Moore, Nicholas A.

In: Journal of Glaucoma, Vol. 25, No. 9, 2016, p. 750-757.

Research output: Contribution to journalArticle

Siesky, Brent ; Harris, Alon ; Carr, Joseph ; Vercellin, Alice Verticchio ; Hussain, Rehan M. ; Hembree, Priyanka Parekh ; Wentz, Scott ; Isaacs, Michael ; Eckert, George ; Moore, Nicholas A. / Reductions in retrobulbar and retinal capillary blood flow strongly correlate with changes in optic nerve head and retinal morphology over 4 years in open-angle glaucoma patients of African descent compared with patients of European descent. In: Journal of Glaucoma. 2016 ; Vol. 25, No. 9. pp. 750-757.
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abstract = "Purpose: To investigate the relationship of changes in ocular blood flow with optic nerve head (ONH) and retinal morphology in openangle glaucoma (OAG) patients of African versus European descent (ED) over 4 years. Materials and Methods: In this study, 112 patients with OAG were examined at baseline, 79 [59 ED, 20 African descent (AD)] of which were followed for 4 years. Retinal capillary blood flow was assessed with Heidelberg retinal flowmetry. Retrobulbar blood flow was measured by color Doppler imaging. Retinal structural changes were examined with optical coherence tomography and Heidelberg retinal tomography-III. Mixed-model analysis of covariance was used to test for the significance of change from baseline to 4-year follow-up, and Pearson correlation coefficients were calculated to evaluate linear associations. Results: In OAG patients of AD, structural changes of the ONH demonstrated a strong association with the end diastolic velocities and resistive indices of the short posterior ciliary arteries over 4 years. In addition, there was a significantly larger increase in the avascular area of the inferior retina in patients of AD, and this reduction in retinal capillaries strongly correlated with a reduction in macular thickness. Conclusions: Reductions in retinal capillary and retrobulbar blood flow strongly correlated with changes in the ONH and macular thickness over 4 years in OAG patients of AD compared with ED. These data suggest that ocular vascular health may be a more influential contributing factor in the pathophysiology of OAG in patients of AD compared with ED.",
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T1 - Reductions in retrobulbar and retinal capillary blood flow strongly correlate with changes in optic nerve head and retinal morphology over 4 years in open-angle glaucoma patients of African descent compared with patients of European descent

AU - Siesky, Brent

AU - Harris, Alon

AU - Carr, Joseph

AU - Vercellin, Alice Verticchio

AU - Hussain, Rehan M.

AU - Hembree, Priyanka Parekh

AU - Wentz, Scott

AU - Isaacs, Michael

AU - Eckert, George

AU - Moore, Nicholas A.

PY - 2016

Y1 - 2016

N2 - Purpose: To investigate the relationship of changes in ocular blood flow with optic nerve head (ONH) and retinal morphology in openangle glaucoma (OAG) patients of African versus European descent (ED) over 4 years. Materials and Methods: In this study, 112 patients with OAG were examined at baseline, 79 [59 ED, 20 African descent (AD)] of which were followed for 4 years. Retinal capillary blood flow was assessed with Heidelberg retinal flowmetry. Retrobulbar blood flow was measured by color Doppler imaging. Retinal structural changes were examined with optical coherence tomography and Heidelberg retinal tomography-III. Mixed-model analysis of covariance was used to test for the significance of change from baseline to 4-year follow-up, and Pearson correlation coefficients were calculated to evaluate linear associations. Results: In OAG patients of AD, structural changes of the ONH demonstrated a strong association with the end diastolic velocities and resistive indices of the short posterior ciliary arteries over 4 years. In addition, there was a significantly larger increase in the avascular area of the inferior retina in patients of AD, and this reduction in retinal capillaries strongly correlated with a reduction in macular thickness. Conclusions: Reductions in retinal capillary and retrobulbar blood flow strongly correlated with changes in the ONH and macular thickness over 4 years in OAG patients of AD compared with ED. These data suggest that ocular vascular health may be a more influential contributing factor in the pathophysiology of OAG in patients of AD compared with ED.

AB - Purpose: To investigate the relationship of changes in ocular blood flow with optic nerve head (ONH) and retinal morphology in openangle glaucoma (OAG) patients of African versus European descent (ED) over 4 years. Materials and Methods: In this study, 112 patients with OAG were examined at baseline, 79 [59 ED, 20 African descent (AD)] of which were followed for 4 years. Retinal capillary blood flow was assessed with Heidelberg retinal flowmetry. Retrobulbar blood flow was measured by color Doppler imaging. Retinal structural changes were examined with optical coherence tomography and Heidelberg retinal tomography-III. Mixed-model analysis of covariance was used to test for the significance of change from baseline to 4-year follow-up, and Pearson correlation coefficients were calculated to evaluate linear associations. Results: In OAG patients of AD, structural changes of the ONH demonstrated a strong association with the end diastolic velocities and resistive indices of the short posterior ciliary arteries over 4 years. In addition, there was a significantly larger increase in the avascular area of the inferior retina in patients of AD, and this reduction in retinal capillaries strongly correlated with a reduction in macular thickness. Conclusions: Reductions in retinal capillary and retrobulbar blood flow strongly correlated with changes in the ONH and macular thickness over 4 years in OAG patients of AD compared with ED. These data suggest that ocular vascular health may be a more influential contributing factor in the pathophysiology of OAG in patients of AD compared with ED.

KW - Blood flow

KW - Open-angle glaucoma

KW - Optic nerve head

KW - Race

KW - Retina

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