Regeneration Through in vivo Cell Fate Reprogramming for Neural Repair

Wenjiao Tai, Xiao Ming Xu, Chun Li Zhang

Research output: Contribution to journalReview article

Abstract

The adult mammalian central nervous system (CNS) has very limited regenerative capacity upon neural injuries or under degenerative conditions. In recent years, however, significant progress has been made on in vivo cell fate reprogramming for neural regeneration. Resident glial cells can be reprogrammed into neuronal progenitors and mature neurons in the CNS of adult mammals. In this review article, we briefly summarize the current knowledge on innate adult neurogenesis under pathological conditions and then focus on induced neurogenesis through cell fate reprogramming. We discuss how the reprogramming process can be regulated and raise critical issues requiring careful considerations to move the field forward. With emerging evidence, we envision that fate reprogramming-based regenerative medicine will have a great potential for treating neurological conditions such as brain injury, spinal cord injury (SCI), Alzheimer’s disease (AD), Parkinson’s disease (PD), and retinopathy.

Original languageEnglish (US)
Article number107
JournalFrontiers in Cellular Neuroscience
Volume14
DOIs
StatePublished - Apr 24 2020

Keywords

  • Alzheimer’s diseases (AD)
  • Parkinson’s disease (PD)
  • adult neurogenesis
  • in vivo reprogramming
  • retinopathy
  • spinal cord injury (SCI)
  • traumatic brain injury (TBI)

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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