Regenerative therapy for cardiomyopathies

Zi Wang, Xuan Su, Muhammad Ashraf, Il Man Kim, Neal L. Weintraub, Meng Jiang, Yaoliang Tang

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Despite substantial advances in the development of medical and interventional strategies in ischemic and non-ischemic heart diseases, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Stem cell therapy for heart disease has gained traction over the past two decades and is an emerging option for the treatment of myocardial dysfunction. In this review, we summarize the current literature on different types of stem cells and their potential usage in ischemic and non-ischemic heart diseases. We emphasize the clinical utility of stem cells to improve myocardial structural and function, promote microvascular angiogenesis, and diminish scar size and major adverse cardiovascular events.We also discuss the therapeutic potential of microvesicles, such as exosomes, in the treatment of CVDs, which may open novel avenues for further clinical studies.

Original languageEnglish (US)
Pages (from-to)357-365
Number of pages9
JournalJournal of cardiovascular translational research
Volume11
Issue number5
DOIs
StatePublished - Jan 1 2018

Keywords

  • Angiogenesis
  • Exosomes
  • Ischemic heart diseases
  • Microvesicles
  • Non-ischemic heart diseases
  • Stem cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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  • Cite this

    Wang, Z., Su, X., Ashraf, M., Kim, I. M., Weintraub, N. L., Jiang, M., & Tang, Y. (2018). Regenerative therapy for cardiomyopathies. Journal of cardiovascular translational research, 11(5), 357-365. https://doi.org/10.1007/s12265-018-9807-z