Regenerative urinary bladder augmentation using small intestinal submucosa: Urodynamic and histopathologic assessment in long-term canine bladder augmentations

Bradley P. Kropp, Marian K. Rippy, Stephen F. Badylak, Mark C. Adams, Michael A. Keating, Richard C. Rink, Karl B. Thor

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

Purpose: To evaluate small intestinal submucosa (SIS) as a possible bladder augmentation material. Materials and Methods: Nineteen male dogs underwent 35 to 45% partial cystectomy with immediate augmentation with SIS grafts. All dogs were evaluated pre- and postoperatively with blood chemistries, urine cultures, intravenous urograms, cystograms and cystometrograms. Postoperatively (1 to 15 months), bladders were examined with routine histology and image analysis. Results: All dogs survived their intended survival period without morbidity. All results were normal. Histologically, all 3 layers (mucosa, smooth muscle, serosa) of the normal bladder showed evidence of regeneration. Conclusions: Small intestinal submucosa acts as a scaffold for bladder augmentation through regeneration and could be a potential option for bladder reconstruction.

Original languageEnglish (US)
Pages (from-to)2098-2104
Number of pages7
JournalJournal of Urology
Volume155
Issue number6
DOIs
StatePublished - Jun 1996
Externally publishedYes

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Urodynamics
Canidae
Urinary Bladder
Dogs
Regeneration
Serous Membrane
Urography
Cystectomy
Smooth Muscle
Histology
Urine
Morbidity
Transplants

Keywords

  • biocompatible materials
  • bladder
  • regeneration

ASJC Scopus subject areas

  • Urology

Cite this

Regenerative urinary bladder augmentation using small intestinal submucosa : Urodynamic and histopathologic assessment in long-term canine bladder augmentations. / Kropp, Bradley P.; Rippy, Marian K.; Badylak, Stephen F.; Adams, Mark C.; Keating, Michael A.; Rink, Richard C.; Thor, Karl B.

In: Journal of Urology, Vol. 155, No. 6, 06.1996, p. 2098-2104.

Research output: Contribution to journalArticle

Kropp, Bradley P. ; Rippy, Marian K. ; Badylak, Stephen F. ; Adams, Mark C. ; Keating, Michael A. ; Rink, Richard C. ; Thor, Karl B. / Regenerative urinary bladder augmentation using small intestinal submucosa : Urodynamic and histopathologic assessment in long-term canine bladder augmentations. In: Journal of Urology. 1996 ; Vol. 155, No. 6. pp. 2098-2104.
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