Regenerative urinary bladder augmentation using small intestinal submucosa: Urodynamic and histopathologic assessment in long-term canine bladder augmentations

Bradley P. Kropp, Marian K. Rippy, Stephen F. Badylak, Mark C. Adams, Michael A. Keating, Richard C. Rink, Karl B. Thor

Research output: Contribution to journalArticle

290 Scopus citations

Abstract

Purpose: To evaluate small intestinal submucosa (SIS) as a possible bladder augmentation material. Materials and Methods: Nineteen male dogs underwent 35 to 45% partial cystectomy with immediate augmentation with SIS grafts. All dogs were evaluated pre- and postoperatively with blood chemistries, urine cultures, intravenous urograms, cystograms and cystometrograms. Postoperatively (1 to 15 months), bladders were examined with routine histology and image analysis. Results: All dogs survived their intended survival period without morbidity. All results were normal. Histologically, all 3 layers (mucosa, smooth muscle, serosa) of the normal bladder showed evidence of regeneration. Conclusions: Small intestinal submucosa acts as a scaffold for bladder augmentation through regeneration and could be a potential option for bladder reconstruction.

Original languageEnglish (US)
Pages (from-to)2098-2104
Number of pages7
JournalJournal of Urology
Volume155
Issue number6
DOIs
StatePublished - Jun 1996

Keywords

  • biocompatible materials
  • bladder
  • regeneration

ASJC Scopus subject areas

  • Urology

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