Regenstrief Medical Informatics. Experiences with Clinical Decision Support Systems.

Paul Biondich, Brian E. Dixon, Jon Duke, Burke Mamlin, Shaun Grannis, Blaine Takesue, Steve Downs, William Tierney

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


The discipline of clinical informatics endeavors to improve the process and outcomes of health care by enabling efficient access to information. Care providers can then use this information, both in the form of medical knowledge and in the form of patient data collected during clinical practice, to make decisions and comply with appropriate standards of care. The Regenstrief Institute began work on clinical information systems in 1972, when Dr. Clement McDonald and colleagues conceptualized and began construction of a computerized patient management system for outpatient diabetes care, developed to meet three primary goals: first, it was built to eliminate the problems inherent in paper records by making clinical data available to authorized users "just-in-time" as medical decisions are made; second, it was designed to aid in the recognition of diagnoses and adoption of pertinent care practices by assisting clinicians during their record-keeping activities; third, the system was designed to aggregate and analyze clinical information to be used in health care support systems, such as those for public health, health services research, and quality improvement. The first installation of the Regenstrief Medical Record System (RMRS) at Wishard Memorial Hospital occurred in 1974 and, over the next few years, the use of this system expanded outside of the diabetic clinic into a few of the hospital's many general medicine clinics. From early in its history, the Regenstrief system has included mechanisms for tailoring rules based on the data, to generate reminders and alerts to care providers. This chapter provides a history of the development and growth of the RMRS into a region-wide source of clinical data, the Indiana Network for Patient Care (INPC), and a summary of the research on the decision support interventions themselves, made possible by this infrastructure. Additionally, lessons learned throughout the more than 30 years of experience in both building and maintaining this system are detailed, alongside some reflections that may be useful for future system builders.

Original languageEnglish (US)
Title of host publicationClinical Decision Support
Subtitle of host publicationThe Road to Broad Adoption: Second Edition
PublisherElsevier Inc.
Number of pages23
ISBN (Print)9780123984760
StatePublished - May 2014


  • Clinical informatics
  • Computerized physician order entry (CPOE)
  • Health information exchange
  • Indiana Network for Patient Care (INPC)
  • Regenstrief Medical Record System

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Regenstrief Medical Informatics. Experiences with Clinical Decision Support Systems.'. Together they form a unique fingerprint.

Cite this