Regional atrophy associated with cognitive and motor function in prodromal huntington disease

The PREDICT-HD Investigators and Coordinators of the Huntington Study Group

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Background: Neuroimaging studies suggest that volumetric MRI measures of specific brain structures may serve as excellent biomarkers in future clinical trials of Huntington disease (HD). Objective: Demonstration of the clinical significance of these measures is an important step in determining their appropriateness as potential outcome measures. Methods: Measures of gray- and white-matter lobular volumes and subcortical volumes (caudate, putamen, globus pallidus, thalamus, nucleus accumbens, hippocampus) were obtained from MRI scans of 516 individuals who tested positive for the HD gene expansion, but were not yet exhibiting signs or symptoms severe enough to warrant diagnosis ("pre-HD"). MRI volumes (corrected for intracranial volume) were correlated with cognitive, motor, psychiatric, and functional measures known to be sensitive to subtle changes in pre-HD. Results: Caudate, putamen, and globus pallidus volumes consistently correlated with cognitive and motor, but not psychiatric or functional measures in pre-HD. Volumes of white matter, nucleus accumbens, and thalamus, but not cortical gray matter, also correlated with some of the motor and cognitive measures. Conclusions: Results of regression analyses suggest that volumes of basal ganglia structures contributed more highly to the prediction of most motor and cognitive variables than volumes of other brain regions. These results support the use of volumetric measures, especially of the basal ganglia, as outcome measures in future clinical trials in pre-HD. Results may also assist investigators in selecting the most appropriate measures for treatment trials that target specific clinical features or regions of neuropathology.

Original languageEnglish (US)
Pages (from-to)477-489
Number of pages13
JournalJournal of Huntington's Disease
Volume2
Issue number4
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Cognitive
  • Huntington disease
  • Magnetic resonance imaging
  • Motor
  • Psychiatric

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Regional atrophy associated with cognitive and motor function in prodromal huntington disease'. Together they form a unique fingerprint.

  • Cite this