Regional brain atrophy in HIV-1 infection

Association with specific neuropsychological test performance

K. Hestad, J. H. McArthur, G. J. Dal Pan, O. A. Selnes, T. E. Nance-Sproson, E. Aylward, Vincent Mathews, J. C. McArthur

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Quantified magnetic resonance imaging (MRI) was related to neuropsychological (NP) test scores in an asymptomatic HIV-1 seropositive group, a non-demented AIDS/ARC group, a group of subjects with HIV-1 dementia, and a seronegative control group. The MRIs were quantified using three planimetric measures of brain structure: the bicaudate ratio (a measure of caudate region atrophy), the bifrontal ratio (a measure of frontal region atrophy), and the ventricle to brain ratio (a measure of overall cerebral atrophy). Cognitive performance was assessed with standard NP tests. Significant correlations between the MRI ratios and many of the NP tests were observed. Of the tests grooved pegboard, part B of the trail making test, the verbal fluency test, and the digit span forward were associated with MRI abnormalities. The bicaudate ratio was most closely associated with the NP tests. These findings indicate that ventricular enlargement, especially in the region of the caudate, is closely related to poor NP test performance in HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)112-118
Number of pages7
JournalActa Neurologica Scandinavica
Volume88
Issue number2
StatePublished - 1993
Externally publishedYes

Fingerprint

Neuropsychological Tests
HIV Infections
Atrophy
HIV-1
Brain
Magnetic Resonance Imaging
AIDS Dementia Complex
Trail Making Test
AIDS-Related Complex
Acquired Immunodeficiency Syndrome
Control Groups

Keywords

  • AIDS
  • Dementia
  • HIV-1 infection
  • Magnetic resonance imaging
  • Neuropsychology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Hestad, K., McArthur, J. H., Dal Pan, G. J., Selnes, O. A., Nance-Sproson, T. E., Aylward, E., ... McArthur, J. C. (1993). Regional brain atrophy in HIV-1 infection: Association with specific neuropsychological test performance. Acta Neurologica Scandinavica, 88(2), 112-118.

Regional brain atrophy in HIV-1 infection : Association with specific neuropsychological test performance. / Hestad, K.; McArthur, J. H.; Dal Pan, G. J.; Selnes, O. A.; Nance-Sproson, T. E.; Aylward, E.; Mathews, Vincent; McArthur, J. C.

In: Acta Neurologica Scandinavica, Vol. 88, No. 2, 1993, p. 112-118.

Research output: Contribution to journalArticle

Hestad, K, McArthur, JH, Dal Pan, GJ, Selnes, OA, Nance-Sproson, TE, Aylward, E, Mathews, V & McArthur, JC 1993, 'Regional brain atrophy in HIV-1 infection: Association with specific neuropsychological test performance', Acta Neurologica Scandinavica, vol. 88, no. 2, pp. 112-118.
Hestad K, McArthur JH, Dal Pan GJ, Selnes OA, Nance-Sproson TE, Aylward E et al. Regional brain atrophy in HIV-1 infection: Association with specific neuropsychological test performance. Acta Neurologica Scandinavica. 1993;88(2):112-118.
Hestad, K. ; McArthur, J. H. ; Dal Pan, G. J. ; Selnes, O. A. ; Nance-Sproson, T. E. ; Aylward, E. ; Mathews, Vincent ; McArthur, J. C. / Regional brain atrophy in HIV-1 infection : Association with specific neuropsychological test performance. In: Acta Neurologica Scandinavica. 1993 ; Vol. 88, No. 2. pp. 112-118.
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