Regional Brain Function in Schizophrenia: I. A Positron Emission Tomography Study

Raquel E. Gur, Susan M. Resnick, Abass Alavi, Ruben C. Gur, Stanley Caroff, Robert Dann, Frank L. Silver, Andrew J. Saykin, John B. Chawluk, Michael Kushner, Martin Reivich

Research output: Contribution to journalArticle

153 Scopus citations


Local cerebral glucose metabolism was determined with 18-F-fluorodeoxyglucose using positron emission tomography in a sample of 12 unmedicated schizophrenics and 12 matched normal controls. The data were analyzed for absolute metabolic rates and region/whole-brain ratios using the cortical-subcortical, antero-posterior, and laterality dimensions. Lobar areas within cortical regions were also compared. Across groups, subcortical metabolism was higher than cortical metabolism. Patients had lower metabolism, cortically and subcortically, and a steeper subcortical to cortical gradient. Patients with higher scores on the Brief Psychiatric Rating Scale had higher absolute metabolism and higher left relative to right hemispheric metabolism than did patients with lesser severity. The results did not show “hypofrontality” in schizophrenia. These findings provide some support for cerebral dysfunction in schizophrenia and indicate the need for further examination of the cortical-subcortical dimension.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalArchives of general psychiatry
Issue number2
StatePublished - Feb 1987
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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    Gur, R. E., Resnick, S. M., Alavi, A., Gur, R. C., Caroff, S., Dann, R., Silver, F. L., Saykin, A. J., Chawluk, J. B., Kushner, M., & Reivich, M. (1987). Regional Brain Function in Schizophrenia: I. A Positron Emission Tomography Study. Archives of general psychiatry, 44(2), 119-125.