Regional Brain Function in Schizophrenia: I. A Positron Emission Tomography Study

Raquel E. Gur, Susan M. Resnick, Abass Alavi, Ruben C. Gur, Stanley Caroff, Robert Dann, Frank L. Silver, Andrew Saykin, John B. Chawluk, Michael Kushner, Martin Reivich

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Local cerebral glucose metabolism was determined with 18-F-fluorodeoxyglucose using positron emission tomography in a sample of 12 unmedicated schizophrenics and 12 matched normal controls. The data were analyzed for absolute metabolic rates and region/whole-brain ratios using the cortical-subcortical, antero-posterior, and laterality dimensions. Lobar areas within cortical regions were also compared. Across groups, subcortical metabolism was higher than cortical metabolism. Patients had lower metabolism, cortically and subcortically, and a steeper subcortical to cortical gradient. Patients with higher scores on the Brief Psychiatric Rating Scale had higher absolute metabolism and higher left relative to right hemispheric metabolism than did patients with lesser severity. The results did not show “hypofrontality” in schizophrenia. These findings provide some support for cerebral dysfunction in schizophrenia and indicate the need for further examination of the cortical-subcortical dimension.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalArchives of General Psychiatry
Volume44
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

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Positron-Emission Tomography
Schizophrenia
Brain
Brief Psychiatric Rating Scale
Fluorodeoxyglucose F18
Metabolism
Positron Emission Tomography
Glucose

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Gur, R. E., Resnick, S. M., Alavi, A., Gur, R. C., Caroff, S., Dann, R., ... Reivich, M. (1987). Regional Brain Function in Schizophrenia: I. A Positron Emission Tomography Study. Archives of General Psychiatry, 44(2), 119-125. https://doi.org/10.1001/archpsyc.1987.01800140021003

Regional Brain Function in Schizophrenia : I. A Positron Emission Tomography Study. / Gur, Raquel E.; Resnick, Susan M.; Alavi, Abass; Gur, Ruben C.; Caroff, Stanley; Dann, Robert; Silver, Frank L.; Saykin, Andrew; Chawluk, John B.; Kushner, Michael; Reivich, Martin.

In: Archives of General Psychiatry, Vol. 44, No. 2, 1987, p. 119-125.

Research output: Contribution to journalArticle

Gur, RE, Resnick, SM, Alavi, A, Gur, RC, Caroff, S, Dann, R, Silver, FL, Saykin, A, Chawluk, JB, Kushner, M & Reivich, M 1987, 'Regional Brain Function in Schizophrenia: I. A Positron Emission Tomography Study', Archives of General Psychiatry, vol. 44, no. 2, pp. 119-125. https://doi.org/10.1001/archpsyc.1987.01800140021003
Gur, Raquel E. ; Resnick, Susan M. ; Alavi, Abass ; Gur, Ruben C. ; Caroff, Stanley ; Dann, Robert ; Silver, Frank L. ; Saykin, Andrew ; Chawluk, John B. ; Kushner, Michael ; Reivich, Martin. / Regional Brain Function in Schizophrenia : I. A Positron Emission Tomography Study. In: Archives of General Psychiatry. 1987 ; Vol. 44, No. 2. pp. 119-125.
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