Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats

J. M. Murphy, W. J. McBride, L. Lumeng, T. K. Li

Research output: Contribution to journalArticle

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Abstract

Regional brain levels of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA) and norepinephrine (NE) were determined in alcohol-naive rats from lines selectively bred for alcohol preference (P) and alcohol aversion (nonpreference, NP). Based on comparison by a standard t-test, the P rats had 12% lower NE in the pons-medulla, 20% higher NE and 16% lower DA content in the cerebral cortex (CX) than did the NP rats. However, the predominant finding was that the levels of 5-HT and 5-HIAA were 12-26% lower for the P than for the NP rats in the CX, hippocampus (HIP), corpus striatum (STR), thalamus (TH) and hypothalamus (HY). Regional CNS monoamines from a group of independently bred, stock Wistar rats were also compared with the NP and P groups to determine if the selectively bred rats differed widely from an unselected population. In most instances, the NP and P rats fell within the range of the stock group. When the stock group was included in an analysis of variance of the data, post-hoc differences between the NP and P groups that remained significant were the lower levels of 5-HT (and in some cases 5-HIAA) in the CX, HIP, STR, TH and HY of the P group. In the HY and HIP, the 5-HT levels of the P and NP animals diverged significantly in opposite directions from those of the stock group, possibly suggesting an involvement of these regional serotonergic systems in alcohol preference.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume16
Issue number1
DOIs
StatePublished - 1982

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Rats
Brain
Alcohols
Serotonin
Hydroxyindoleacetic Acid
Hypothalamus
Hippocampus
Norepinephrine
Thalamus
Dopamine
Corpus Striatum
Pons
Cerebral Cortex
Analysis of variance (ANOVA)
Wistar Rats
Analysis of Variance
Animals
Population

Keywords

  • 5-Hydroxyindoleacetic acid
  • Alcohol-preferring rats
  • Dopamine
  • Norepinephrine
  • Regional brain monoamines
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats. / Murphy, J. M.; McBride, W. J.; Lumeng, L.; Li, T. K.

In: Pharmacology Biochemistry and Behavior, Vol. 16, No. 1, 1982, p. 145-149.

Research output: Contribution to journalArticle

Murphy, J. M. ; McBride, W. J. ; Lumeng, L. ; Li, T. K. / Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats. In: Pharmacology Biochemistry and Behavior. 1982 ; Vol. 16, No. 1. pp. 145-149.
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