Regional differences in the development of tolerance to the action of morphine on 5-hydroxytryptamine containing neurons in the rat

Michael Vasko, M. Vogt

Research output: Contribution to journalArticle

Abstract

Studies of the effect of alteration of brain 5-hydroxytryptamine (5-HT) on morphine analgesia suggest that activation of 5-HT containing neurons is involved in the antinociceptive action of morphine (Tenen, 1968; Vogt, 1974). Rapid tolerance has been shown to develop to the analgesic effect of morphine but not to the acceleration of 5-HT turnover in whole brain. The present work determines whether tolerance develops to the action of morphine on 5-HT turnover in discrete areas of the central nervous system. While there was no evidence that tolerance to the effect of morphine on 5-HT turnover occurs in the brain, it was found to exist in the spinal cord.

Original languageEnglish (US)
JournalJournal of Physiology
VolumeVol. 313
StatePublished - 1981
Externally publishedYes

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Morphine
Serotonin
Neurons
Brain
Analgesia
Analgesics
Spinal Cord
Central Nervous System

ASJC Scopus subject areas

  • Physiology

Cite this

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AB - Studies of the effect of alteration of brain 5-hydroxytryptamine (5-HT) on morphine analgesia suggest that activation of 5-HT containing neurons is involved in the antinociceptive action of morphine (Tenen, 1968; Vogt, 1974). Rapid tolerance has been shown to develop to the analgesic effect of morphine but not to the acceleration of 5-HT turnover in whole brain. The present work determines whether tolerance develops to the action of morphine on 5-HT turnover in discrete areas of the central nervous system. While there was no evidence that tolerance to the effect of morphine on 5-HT turnover occurs in the brain, it was found to exist in the spinal cord.

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