Studies of the effect of alteration of brain 5-hydroxytryptamine (5-HT) on morphine analgesia suggest that activation of 5-HT containing neurons is involved in the antinociceptive action of morphine (Tenen, 1968; Vogt, 1974). Rapid tolerance has been shown to develop to the analgesic effect of morphine but not to the acceleration of 5-HT turnover in whole brain. The present work determines whether tolerance develops to the action of morphine on 5-HT turnover in discrete areas of the central nervous system. While there was no evidence that tolerance to the effect of morphine on 5-HT turnover occurs in the brain, it was found to exist in the spinal cord.
|Original language||English (US)|
|Journal||Journal of Physiology|
|State||Published - Jan 1 1981|
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