Regional myocardial perfusion assessed with generator-produced copper- 62-PTSM and PET

Pilar Herrero, Judy J. Hartman, Mark Green, Carolyn J. Anderson, Michael J. Welch, Joanne Markham, Steven R. Bergmann

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

We have previously demonstrated that myocardial perfusion can be estimated accurately in experimental animals with the generator-produced positron-emitting tracer, 62Cu-pyruvaldehyde bis (N4-methylthio- semicarbazone)(62Cu-PTSM) and PET. This study evaluated the feasibility of quantifying regional myocardial blood flow using 62Cu-PTSM and PET in human subjects. Methods: Regional perfusion was estimated using a previously described and validated two-compartment model from dynamic PET scans obtained after an intravenous bolus of 62Cu-PTSM in 10 healthy volunteers and in 6 patients with coronary artery disease at rest; and in 9 of the volunteers and 4 of the patients after administration of dipyridamole intravenously. Flow estimates were compared with those obtained using H2-15O. Results: Contrast was high between myocardium and blood or lung with 62Cu-PTSM, resulting in high-quality myocardial images. Liver uptake was also high. At flows of up to 1.5 ml/g/min, flow estimated with 62Cu-PTSM correlated closely with estimates obtained with H215O (y = 0.71x + 0.21, n = 169 regional comparisons, r = 0.66, p <0.05), but this relationship was not maintained at higher flows. Conclusion: The results demonstrate that quantification of myocardial perfusion with 62Cu-PTSM is feasible in human subjects but cannot be used to estimate hyperemic flows due most likely to the strong binding of the tracer to human serum albumin. Copper-62-PTSM congeners with less avidity for human albumin may prove more suitable for evaluation of hyperemic flows.

Original languageEnglish (US)
Pages (from-to)1294-3000
Number of pages1707
JournalJournal of Nuclear Medicine
Volume37
Issue number8
StatePublished - Aug 1996
Externally publishedYes

Fingerprint

Copper
Perfusion
Semicarbazones
Pyruvaldehyde
Dipyridamole
Regional Blood Flow
Feasibility Studies
Serum Albumin
Positron-Emission Tomography
Coronary Artery Disease
Volunteers
Albumins
Myocardium
Healthy Volunteers
Electrons
Lung
Liver

Keywords

  • copper-62-PTSM
  • myocardial blood flow
  • PET

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Herrero, P., Hartman, J. J., Green, M., Anderson, C. J., Welch, M. J., Markham, J., & Bergmann, S. R. (1996). Regional myocardial perfusion assessed with generator-produced copper- 62-PTSM and PET. Journal of Nuclear Medicine, 37(8), 1294-3000.

Regional myocardial perfusion assessed with generator-produced copper- 62-PTSM and PET. / Herrero, Pilar; Hartman, Judy J.; Green, Mark; Anderson, Carolyn J.; Welch, Michael J.; Markham, Joanne; Bergmann, Steven R.

In: Journal of Nuclear Medicine, Vol. 37, No. 8, 08.1996, p. 1294-3000.

Research output: Contribution to journalArticle

Herrero, P, Hartman, JJ, Green, M, Anderson, CJ, Welch, MJ, Markham, J & Bergmann, SR 1996, 'Regional myocardial perfusion assessed with generator-produced copper- 62-PTSM and PET', Journal of Nuclear Medicine, vol. 37, no. 8, pp. 1294-3000.
Herrero P, Hartman JJ, Green M, Anderson CJ, Welch MJ, Markham J et al. Regional myocardial perfusion assessed with generator-produced copper- 62-PTSM and PET. Journal of Nuclear Medicine. 1996 Aug;37(8):1294-3000.
Herrero, Pilar ; Hartman, Judy J. ; Green, Mark ; Anderson, Carolyn J. ; Welch, Michael J. ; Markham, Joanne ; Bergmann, Steven R. / Regional myocardial perfusion assessed with generator-produced copper- 62-PTSM and PET. In: Journal of Nuclear Medicine. 1996 ; Vol. 37, No. 8. pp. 1294-3000.
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abstract = "We have previously demonstrated that myocardial perfusion can be estimated accurately in experimental animals with the generator-produced positron-emitting tracer, 62Cu-pyruvaldehyde bis (N4-methylthio- semicarbazone)(62Cu-PTSM) and PET. This study evaluated the feasibility of quantifying regional myocardial blood flow using 62Cu-PTSM and PET in human subjects. Methods: Regional perfusion was estimated using a previously described and validated two-compartment model from dynamic PET scans obtained after an intravenous bolus of 62Cu-PTSM in 10 healthy volunteers and in 6 patients with coronary artery disease at rest; and in 9 of the volunteers and 4 of the patients after administration of dipyridamole intravenously. Flow estimates were compared with those obtained using H2-15O. Results: Contrast was high between myocardium and blood or lung with 62Cu-PTSM, resulting in high-quality myocardial images. Liver uptake was also high. At flows of up to 1.5 ml/g/min, flow estimated with 62Cu-PTSM correlated closely with estimates obtained with H215O (y = 0.71x + 0.21, n = 169 regional comparisons, r = 0.66, p <0.05), but this relationship was not maintained at higher flows. Conclusion: The results demonstrate that quantification of myocardial perfusion with 62Cu-PTSM is feasible in human subjects but cannot be used to estimate hyperemic flows due most likely to the strong binding of the tracer to human serum albumin. Copper-62-PTSM congeners with less avidity for human albumin may prove more suitable for evaluation of hyperemic flows.",
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AU - Bergmann, Steven R.

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