Regional variation and age-related changes of lysosomal enzymes in the human retinal pigment epithelium

M. Boulton, P. Moriarty, J. Jarvis-Evans, B. Marcyniuk

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In this study the activities of two lysosomal enzymes in retinal pigment epithelial (RPE) cells isolated from three regions of the human fundus were examined: the macula, the nasal midzone, and the periphery. The results obtained showed that the activities of acid phosphatase and cathepsin D were significantly higher in the RPE cells derived from the macular region when compared with those in the periphery. The values for the midzone appeared to be intermediate between the other two regions. Furthermore, the overall activity of both enzymes increased as a function of age.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalBritish Journal of Ophthalmology
Issue number2
StatePublished - Jan 1 1994


ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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