Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints

Paul J. Wang, Andrew J. Saykin, Laura A. Flashman, Heather A. Wishart, Laura A. Rabin, Robert B. Santulli, Tara L. McHugh, John W. MacDonald, Alexander C. Mamourian

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

The goal of the present study was to determine if there are global or regionally specific decreases in callosal area in early Alzheimer's disease (AD) and mild cognitive impairment (MCI). In addition, this study examined the corpus callosum of healthy older adults who have subjective cognitive complaints (CC) but perform within normal limits on neuropsychological tests. We used a semi-automated procedure to examine the total and regional areas of the corpus callosum in 22 patients with early AD, 28 patients with amnestic MCI, 28 healthy older adults with cognitive complaints, and 50 demographically matched healthy controls (HC). The AD, MCI, and CC groups all showed a significant reduction of the posterior region (isthmus and splenium) relative to healthy controls. The AD group also had a significantly smaller overall callosum than the controls. The demonstration of callosal atrophy in older adults with cognitive complaints suggests that callosal changes occur very early in the dementing process, and that these earliest changes may be too subtle for detection by neuropsychological assessments, including memory tests.

Original languageEnglish (US)
Pages (from-to)1613-1617
Number of pages5
JournalNeurobiology of Aging
Volume27
Issue number11
DOIs
StatePublished - Nov 1 2006
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Cognitive complaints
  • Corpus callosum
  • Magnetic resonance imaging
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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    Wang, P. J., Saykin, A. J., Flashman, L. A., Wishart, H. A., Rabin, L. A., Santulli, R. B., McHugh, T. L., MacDonald, J. W., & Mamourian, A. C. (2006). Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints. Neurobiology of Aging, 27(11), 1613-1617. https://doi.org/10.1016/j.neurobiolaging.2005.09.035