Regulating the adaptive immune response to respiratory virus infection

Thomas J. Braciale, Jie Sun, Taeg S. Kim

Research output: Contribution to journalReview article

149 Citations (Scopus)

Abstract

Recent years have seen several advances in our understanding of immunity to virus infection of the lower respiratory tract, including to influenza virus infection. Here, we review the cellular targets of viruses and the features of the host immune response that are unique to the lungs. We describe the interplay between innate and adaptive immune cells in the induction, expression and control of antiviral immunity, and discuss the impact of the infected lung milieu on moulding the response of antiviral effector T cells. Recent findings on the mechanisms that underlie the increased frequency of severe pulmonary bacterial infections following respiratory virus infection are also discussed.

Original languageEnglish (US)
Pages (from-to)295-305
Number of pages11
JournalNature Reviews Immunology
Volume12
Issue number4
DOIs
StatePublished - Apr 1 2012

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Adaptive Immunity
Virus Diseases
Respiratory Tract Infections
Lung
Antiviral Agents
Immunity
Orthomyxoviridae
Bacterial Infections
Respiratory System
Viruses
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Regulating the adaptive immune response to respiratory virus infection. / Braciale, Thomas J.; Sun, Jie; Kim, Taeg S.

In: Nature Reviews Immunology, Vol. 12, No. 4, 01.04.2012, p. 295-305.

Research output: Contribution to journalReview article

Braciale, Thomas J. ; Sun, Jie ; Kim, Taeg S. / Regulating the adaptive immune response to respiratory virus infection. In: Nature Reviews Immunology. 2012 ; Vol. 12, No. 4. pp. 295-305.
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