Regulation of angiotensinogen gene

E. Clauser, I. Gaillard, Lei Wei, P. Corvol

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The development of recombinant DNA technology has introduced new directions for the study of the angiotensinogen molecule. The cloning and sequencing of the human and rat cDNAs demonstrate the similarity of angiotensinogen to various serine protease inhibitors produced by the liver and was the beginning of studies looking for new physiological roles of angiotensinogen, in addition to the substrate for renin. The determination of the nucleotide sequence of these cDNAs also allowed the identification of angiotensinogen mRNA in many tissues in addition to the liver that is the major site of synthesis. This multilocalization of angiotensinogen is one of the arguments for the presence and the function of local renin-angiotensin systems. Finally, the hepatic biosynthesis of angiotensinogen is regulated by many different hormonal factors including glucocorticoid, estrogen, thyroid hormone, insulin, and angiotensin II. The cloning of the angiotensinogen gene offers the opportunity to study this regulation at the transcriptional level. We present in this paper a review of the literature concerning the new aspects of angiotensinogen using molecular biological tools and its regulation together with the characterization of the human angiotensinogen gene.

Original languageEnglish (US)
Pages (from-to)403-410
Number of pages8
JournalAmerican Journal of Hypertension
Volume2
Issue number5 I
StatePublished - 1989
Externally publishedYes

Fingerprint

Angiotensinogen
Genes
Organism Cloning
Liver
Complementary DNA
Serine Proteinase Inhibitors
Recombinant DNA
Renin-Angiotensin System
Thyroid Hormones
Angiotensin II
Glucocorticoids
Estrogens
Insulin
Technology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Clauser, E., Gaillard, I., Wei, L., & Corvol, P. (1989). Regulation of angiotensinogen gene. American Journal of Hypertension, 2(5 I), 403-410.

Regulation of angiotensinogen gene. / Clauser, E.; Gaillard, I.; Wei, Lei; Corvol, P.

In: American Journal of Hypertension, Vol. 2, No. 5 I, 1989, p. 403-410.

Research output: Contribution to journalArticle

Clauser, E, Gaillard, I, Wei, L & Corvol, P 1989, 'Regulation of angiotensinogen gene', American Journal of Hypertension, vol. 2, no. 5 I, pp. 403-410.
Clauser E, Gaillard I, Wei L, Corvol P. Regulation of angiotensinogen gene. American Journal of Hypertension. 1989;2(5 I):403-410.
Clauser, E. ; Gaillard, I. ; Wei, Lei ; Corvol, P. / Regulation of angiotensinogen gene. In: American Journal of Hypertension. 1989 ; Vol. 2, No. 5 I. pp. 403-410.
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