Abstract
Branched-chain α-keto acid dehydrogenase kinase is responsible for the inactivation and phosphorylation of the branched-chain α-keto acid dehydrogenase complex, the enzyme that catalyses the committed step of branched-chain amino acid catabolism. The activity of the branched-chain α-keto acid dehydrogenase complex is inversely correlated with kinase activity, suggesting that the relative activity of the kinase is the primary regulator of the activity of the complex. It has been shown that kinase activity and expression are affected by nutritional states imposed by low-protein diet feeding, starvation, diabetes, and exercise. Evidence has also been presented that certain hormones, particularly insulin, glucocorticoid, thyroid hormone and female sex hormones, affect the activity and expression of the kinase. The findings indicate that nutritional and hormonal control of the activity and expression of branched-chain α-keto acid dehydrogenase kinase provides an important means of control of the activity of the branched-chain α-keto acid dehydrogenase complex, with inactivation serving to conserve branched-chain amino acids for protein synthesis in some situations and activation serving to provide carbon for gluconeogenesis in others.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 419-423 |
| Number of pages | 5 |
| Journal | Current Opinion in Clinical Nutrition and Metabolic Care |
| Volume | 4 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Endocrinology
- Food Science
- Endocrinology, Diabetes and Metabolism
Cite this
Regulation of branched-chain amino acid catabolism : Nutritional and hormonal regulation of activity and expression of the branched-chain α-keto acid dehydrogenase kinase. / Shimomura, Yoshiharu; Obayashi, Mariko; Murakami, Taro; Harris, Robert.
In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 4, No. 5, 2001, p. 419-423.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of branched-chain amino acid catabolism
T2 - Nutritional and hormonal regulation of activity and expression of the branched-chain α-keto acid dehydrogenase kinase
AU - Shimomura, Yoshiharu
AU - Obayashi, Mariko
AU - Murakami, Taro
AU - Harris, Robert
PY - 2001
Y1 - 2001
N2 - Branched-chain α-keto acid dehydrogenase kinase is responsible for the inactivation and phosphorylation of the branched-chain α-keto acid dehydrogenase complex, the enzyme that catalyses the committed step of branched-chain amino acid catabolism. The activity of the branched-chain α-keto acid dehydrogenase complex is inversely correlated with kinase activity, suggesting that the relative activity of the kinase is the primary regulator of the activity of the complex. It has been shown that kinase activity and expression are affected by nutritional states imposed by low-protein diet feeding, starvation, diabetes, and exercise. Evidence has also been presented that certain hormones, particularly insulin, glucocorticoid, thyroid hormone and female sex hormones, affect the activity and expression of the kinase. The findings indicate that nutritional and hormonal control of the activity and expression of branched-chain α-keto acid dehydrogenase kinase provides an important means of control of the activity of the branched-chain α-keto acid dehydrogenase complex, with inactivation serving to conserve branched-chain amino acids for protein synthesis in some situations and activation serving to provide carbon for gluconeogenesis in others.
AB - Branched-chain α-keto acid dehydrogenase kinase is responsible for the inactivation and phosphorylation of the branched-chain α-keto acid dehydrogenase complex, the enzyme that catalyses the committed step of branched-chain amino acid catabolism. The activity of the branched-chain α-keto acid dehydrogenase complex is inversely correlated with kinase activity, suggesting that the relative activity of the kinase is the primary regulator of the activity of the complex. It has been shown that kinase activity and expression are affected by nutritional states imposed by low-protein diet feeding, starvation, diabetes, and exercise. Evidence has also been presented that certain hormones, particularly insulin, glucocorticoid, thyroid hormone and female sex hormones, affect the activity and expression of the kinase. The findings indicate that nutritional and hormonal control of the activity and expression of branched-chain α-keto acid dehydrogenase kinase provides an important means of control of the activity of the branched-chain α-keto acid dehydrogenase complex, with inactivation serving to conserve branched-chain amino acids for protein synthesis in some situations and activation serving to provide carbon for gluconeogenesis in others.
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U2 - 10.1097/00075197-200109000-00013
DO - 10.1097/00075197-200109000-00013
M3 - Article
VL - 4
SP - 419
EP - 423
JO - Current Opinion in Clinical Nutrition and Metabolic Care
JF - Current Opinion in Clinical Nutrition and Metabolic Care
SN - 1363-1950
IS - 5
ER -