Regulation of branched-chain amino acid catabolism: Nutritional and hormonal regulation of activity and expression of the branched-chain α-keto acid dehydrogenase kinase

Yoshiharu Shimomura, Mariko Obayashi, Taro Murakami, Robert A. Harris

Research output: Contribution to journalReview article

76 Scopus citations

Abstract

Branched-chain α-keto acid dehydrogenase kinase is responsible for the inactivation and phosphorylation of the branched-chain α-keto acid dehydrogenase complex, the enzyme that catalyses the committed step of branched-chain amino acid catabolism. The activity of the branched-chain α-keto acid dehydrogenase complex is inversely correlated with kinase activity, suggesting that the relative activity of the kinase is the primary regulator of the activity of the complex. It has been shown that kinase activity and expression are affected by nutritional states imposed by low-protein diet feeding, starvation, diabetes, and exercise. Evidence has also been presented that certain hormones, particularly insulin, glucocorticoid, thyroid hormone and female sex hormones, affect the activity and expression of the kinase. The findings indicate that nutritional and hormonal control of the activity and expression of branched-chain α-keto acid dehydrogenase kinase provides an important means of control of the activity of the branched-chain α-keto acid dehydrogenase complex, with inactivation serving to conserve branched-chain amino acids for protein synthesis in some situations and activation serving to provide carbon for gluconeogenesis in others.

Original languageEnglish (US)
Pages (from-to)419-423
Number of pages5
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Volume4
Issue number5
DOIs
StatePublished - Dec 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Regulation of branched-chain amino acid catabolism: Nutritional and hormonal regulation of activity and expression of the branched-chain α-keto acid dehydrogenase kinase'. Together they form a unique fingerprint.

  • Cite this