Signal transducer and activator of transcription (STAT) proteins are a family of signaling and transcription factors. STAT proteins are crucially involved in signaling from many cytokine and growth-factor receptors (1,2). Once a cytokine or growth factor binds to a receptor on the cell surface, it activates receptorassociated tyrosine kinase activity. Tyrosine kinase activity can be either intrinsic to the receptor or be in the form of additional proteins associated with the intracellular portion of the receptor. The Janus tyrosine kinases (JAKs) are the most common tyrosine kinases associated with cytokine-growth factor receptors and activation of STAT proteins and other signaling pathways as well. The JAKs phosphorylate tyrosine residues on the receptor. These phosphorylated tyrosines then serve as docking sites for preexisting and cytoplasmic STAT monomeric proteins.
|Original language||English (US)|
|Title of host publication||Chemokines in the Lung|
|Number of pages||10|
|State||Published - Jan 1 2003|
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