Regulation of coronary blood flow

Adam G. Goodwill, Gregory M. Dick, Alexander M. Kiel, Johnathan Tune

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The heart is uniquely responsible for providing its own blood supply through the coronary circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of dedicated research, is understood to be dictated through multiple mechanisms that include extravascular compressive forces (tissue pressure), coronary perfusion pressure, myogenic, local metabolic, endothelial as well as neural and hormonal influences. While each of these determinants can have profound influence over myocardial perfusion, largely through effects on end-effector ion channels, these mechanisms collectively modulate coronary vascular resistance and act to ensure that the myocardial requirements for oxygen and substrates are adequately provided by the coronary circulation. The purpose of this series of Comprehensive Physiology is to highlight current knowledge regarding the physiologic regulation of coronary blood flow, with emphasis on functional anatomy and the interplay between the physical and biological determinants of myocardial oxygen delivery.

Original languageEnglish (US)
Pages (from-to)321-382
Number of pages62
JournalComprehensive Physiology
Volume7
Issue number2
DOIs
StatePublished - Apr 1 2017

Fingerprint

Coronary Circulation
Perfusion
Oxygen
Pressure
Ion Channels
Vascular Resistance
Anatomy
Research

ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Physiology (medical)

Cite this

Regulation of coronary blood flow. / Goodwill, Adam G.; Dick, Gregory M.; Kiel, Alexander M.; Tune, Johnathan.

In: Comprehensive Physiology, Vol. 7, No. 2, 01.04.2017, p. 321-382.

Research output: Contribution to journalArticle

Goodwill, AG, Dick, GM, Kiel, AM & Tune, J 2017, 'Regulation of coronary blood flow', Comprehensive Physiology, vol. 7, no. 2, pp. 321-382. https://doi.org/10.1002/cphy.c160016
Goodwill, Adam G. ; Dick, Gregory M. ; Kiel, Alexander M. ; Tune, Johnathan. / Regulation of coronary blood flow. In: Comprehensive Physiology. 2017 ; Vol. 7, No. 2. pp. 321-382.
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