Regulation of fetal amino acid metabolism: Substrate or hormonal regulation?

Edward A. Liechty, Scott C. Denne

Research output: Contribution to journalArticle

11 Scopus citations


Insulin is regarded as the primary fetal growth-promoting hormone, but direct in vivo experimental data supporting this conjecture are sparse. Data obtained from studies in in vivo, chronically catheterized fetal lambs under a variety of experimental circumstances demonstrate that glucose availability is the primary modulator of fetal protein accretion, via its ability to diminish amino acid catabolism. The ovine fetus is shown to be resistant to insulin-induced suppression of proteolysis, relative to the adult. Data from studies in the human premature infant show that the findings in the ovine fetus are similar to those in the ex utero premature human.

Original languageEnglish (US)
Pages (from-to)342S-346S
JournalJournal of Nutrition
Issue number2 SUPPL.
StatePublished - Mar 10 1998


  • Insulin
  • Leucine
  • Ovine fetus
  • Tracer kinetics human premature infant

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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