Regulation of fetal amino acid metabolism: Substrate or hormonal regulation?

Edward A. Liechty, Scott Denne

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Insulin is regarded as the primary fetal growth-promoting hormone, but direct in vivo experimental data supporting this conjecture are sparse. Data obtained from studies in in vivo, chronically catheterized fetal lambs under a variety of experimental circumstances demonstrate that glucose availability is the primary modulator of fetal protein accretion, via its ability to diminish amino acid catabolism. The ovine fetus is shown to be resistant to insulin-induced suppression of proteolysis, relative to the adult. Data from studies in the human premature infant show that the findings in the ovine fetus are similar to those in the ex utero premature human.

Original languageEnglish
JournalJournal of Nutrition
Volume128
Issue number2 SUPPL.
StatePublished - 1998

Fingerprint

amino acid metabolism
hormonal regulation
fetus
Sheep
Fetus
insulin
Insulin
Fetal Proteins
Amino Acids
sheep
fetal development
Fetal Development
in vivo studies
Premature Infants
proteolysis
Proteolysis
Growth Hormone
lambs
hormones
Glucose

Keywords

  • Insulin
  • Leucine
  • Ovine fetus
  • Tracer kinetics human premature infant

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Regulation of fetal amino acid metabolism : Substrate or hormonal regulation? / Liechty, Edward A.; Denne, Scott.

In: Journal of Nutrition, Vol. 128, No. 2 SUPPL., 1998.

Research output: Contribution to journalArticle

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