Regulation of gene expression by the proto-oncogene BCL-6

Alexander L. Dent, Farha H. Vasanwala, Lisa M. Toney

Research output: Contribution to journalReview article

75 Scopus citations

Abstract

The proto-oncogene BCL-6 encodes a transcriptional repressor protein that is expressed at high levels in germinal center B cells and lymphomas with a germinal center B cell phenotype. The BCL-6 gene is a frequent target of chromosomal translocations, micro-deletions, and point mutations in non-Hodgkin's lymphoma. Studies of BCL-6-deficient mice have revealed that BCL-6 is critical for normal lymphocyte differentiation and also that BCL-6 is a negative regulator of inflammation. Recent studies have shed light on how BCL-6 controls these processes by showing that BCL-6 regulates a broad spectrum of target genes. BCL-6 represses transcription of genes involved in lymphocyte activation, differentiation, proliferation, and migration. Although much progress has been made in understanding gene regulation by BCL-6, many important questions are unresolved.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalCritical Reviews in Oncology/Hematology
Volume41
Issue number1
DOIs
StatePublished - Jan 21 2002

Keywords

  • BCL-6
  • BCL-6-target genes
  • Lymphoma
  • Transcriptional regulation

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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