Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Maintenance by the PI3K-mTORC1 Pathway

Joydeep Ghosh, Reuben Kapur

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Hematopoietic stem cells (HSC) are the most well-defined stem cell population and have provided invaluable understanding of tissue-specific stem cell development and functions. Aberrant proliferation and differentiation of HSCs cause various hematologic malignancies. Studies have established that within the bulk leukemic population, there are malignant leukemic stem cells (LSCs), which can give rise to leukemia through serial transplantation. LSCs possess similar properties like HSCs, and they can both undergo self-renewal and differentiation. Similarly, HSCs and LSCs both remain in a quiescent state to prevent exhaustion due to proliferation. These processes are tightly regulated by different signaling pathways. Class IA phosphoinositide 3-kinase (PI3K)-mechanistic target of rapamycin complex (mTORC) pathway is a key pathway in regulating HSCs as well as LSCs. In this review, we focus on recent developments regarding the role of different components of the PI3K-mTORC pathway in regulating HSC and LSC functions.

Original languageEnglish (US)
Pages (from-to)368-378
Number of pages11
JournalCurrent Stem Cell Reports
Volume2
Issue number4
DOIs
StatePublished - Dec 1 2016

Keywords

  • Akt
  • Hematopoietic stem cells
  • Leukemia stem cells
  • PTEN
  • Self-renewal
  • mTORC1

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology
  • Cell Biology

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