Regulation of human alcohol dehydrogenase genes

Howard J. Edenberg, Celeste J. Brown

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

This review focuses upon the regulation of the three human class I alcohol dehydrogenase genes, ADH1, ADH2 and ADH3. These closely related genes are expressed at high levels in liver, and at different levels in other tissues. Multiple cis -acting sequences to which nuclear proteins bind have been mapped, and transcription factors that can bind to these sequences have been identified; these include C/EBPa, Spl, USF, HNF1, CTF/NF1, the glucocorticoid receptor, and RARα. There are interesting but often subtle differences in the binding to these three closely related genes, that presumably account for the differences in patterns of their expression.

Original languageEnglish (US)
Pages (from-to)185-196
Number of pages12
JournalPharmacogenetics
Volume2
Issue number5
DOIs
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Genetics
  • Pharmacology, Toxicology and Pharmaceutics(all)

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