Regulation of in vivo growth hormone secretion by leptin

E. Carro, R. Senaris, Robert Considine, F. F. Casanueva, C. Dieguez

Research output: Contribution to journalArticle

325 Citations (Scopus)

Abstract

Leptin, the product of the ob gene, is a recently discovered hormone secreted by adipocytes that regulates food intake and energy expenditure. Growth hormone (GH) secretion is markedly influence by body weight being markedly suppressed in obesity and underweight. The aim of the present study was to study whether leptin can act as a metabolic signal connecting the adipose tissue with the growth hormone axis. We administered leptin antiserum (10 ul, ic.v.) or normal rabbit serum (NRS; 10 ul,i.c.v.) to freely moving fed rats. Furthermore we assessed the effect of leptin administration (10 ug, i.c.v.) on fed and fasted rats. Spontaneous GH secretion was assessed over 6 hours with blood samples taken every 15 min. Administration of leptin antiserum led to a decrease in spontaneous GH secretion as assessed by the area under the curve (AUC) (168±72 ng/ml/6h) in comparison to NRS-treated rats (813±179 ng/ml/6h, p

Original languageEnglish (US)
Pages (from-to)2203-2206
Number of pages4
JournalEndocrinology
Volume138
Issue number5
StatePublished - 1997
Externally publishedYes

Fingerprint

Leptin
Growth Hormone
Immune Sera
Thinness
Adipocytes
Energy Metabolism
Area Under Curve
Adipose Tissue
Obesity
Eating
Body Weight
Hormones
Rabbits
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Carro, E., Senaris, R., Considine, R., Casanueva, F. F., & Dieguez, C. (1997). Regulation of in vivo growth hormone secretion by leptin. Endocrinology, 138(5), 2203-2206.

Regulation of in vivo growth hormone secretion by leptin. / Carro, E.; Senaris, R.; Considine, Robert; Casanueva, F. F.; Dieguez, C.

In: Endocrinology, Vol. 138, No. 5, 1997, p. 2203-2206.

Research output: Contribution to journalArticle

Carro, E, Senaris, R, Considine, R, Casanueva, FF & Dieguez, C 1997, 'Regulation of in vivo growth hormone secretion by leptin', Endocrinology, vol. 138, no. 5, pp. 2203-2206.
Carro E, Senaris R, Considine R, Casanueva FF, Dieguez C. Regulation of in vivo growth hormone secretion by leptin. Endocrinology. 1997;138(5):2203-2206.
Carro, E. ; Senaris, R. ; Considine, Robert ; Casanueva, F. F. ; Dieguez, C. / Regulation of in vivo growth hormone secretion by leptin. In: Endocrinology. 1997 ; Vol. 138, No. 5. pp. 2203-2206.
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