Regulation of Leptin Production

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Fat mass is the primary determinant of serum leptin in humans with energy intake and gender also having significant effects. Gender influences leptin production through the reproductive hormones. Glucose metabolism links food intake to leptin production and hexosamine biosynthesis appears to play a significant role in this process. Catecholamines inhibit leptin production and the sympathetic nervous system has been proposed to be the efferent arm of the leptin signal transduction pathway between adipose tissue and the central nervous system. Additional regulators of leptin production include glucocorticoids, cytokines and agonists of PPARγ. In addition to adipose tissue, leptin is produced in several other places including placenta, bone marrow, stomach, muscle and perhaps brain, thus increasing the number of potential regulatory roles for this hormone. Future work will be needed to fully elucidate the mechanisms regulating leptin synthesis/release in each tissue as well as its regulatory functions.

Original languageEnglish
Pages (from-to)357-363
Number of pages7
JournalReviews in Endocrine and Metabolic Disorders
Volume2
Issue number4
DOIs
StatePublished - 2001

Fingerprint

Leptin
Adipose Tissue
Hormones
Hexosamines
Peroxisome Proliferator-Activated Receptors
Sympathetic Nervous System
Energy Intake
Placenta
Glucocorticoids
Catecholamines
Signal Transduction
Stomach
Central Nervous System
Eating
Bone Marrow
Fats
Cytokines
Glucose
Muscles
Brain

Keywords

  • Adipose tissue
  • Lep gene
  • Leptin
  • Transcription

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine

Cite this

Regulation of Leptin Production. / Considine, Robert.

In: Reviews in Endocrine and Metabolic Disorders, Vol. 2, No. 4, 2001, p. 357-363.

Research output: Contribution to journalArticle

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