Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6

Louis M. Staudt, Alexander L. Dent, A. L. Shaffer, Xin Yu

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Genetic alterations of the BCL-6 gene in mice and man have established BCL-6 as a pivotal regulator of normal differentiation of B and T lymphocytes as well as one of the most frequently translocated oncogenes in human B cell lymphomas. As an oncogene, BCL-6 has not been easy to place into existing paradigms of cellular transformation. Rather, it is likely that the function of BCL-6 as a regulator of lymphocyte differentiation is subverted in BCL-6-induced lymphomas. The lymphomas in which BCL-6 is translocated are all suspected to arise from the germinal center B lymphocyte. Given the selective expression of BCL-6 protein in normal germinal center B lymphocytes and the requirement for BCL-6 in germinal center development, the functions of BCL-6 in normal and malignant B cells are probably intertwined. The BCL-6 protein is a potent transcriptional repressor which presumably controls lymphocyte differentiation and induces lymphomas by regulating the expression of key downstream target genes.

Original languageEnglish (US)
Pages (from-to)381-403
Number of pages23
JournalInternational Reviews of Immunology
Volume18
Issue number4
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • BCL-6
  • Differentiation
  • Germinal center
  • Lymphocyte
  • Lymphoma
  • Th2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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