Regulation of microRNA expression: The hypoxic component

Ritu Kulshreshtha, Manuela Ferracin, Massimo Negrini, George A. Calin, Ramana V. Davuluri, Mircea Ivan

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

microRNAs are involved in a wide variety of normal and pathological cellular processes, including tumorigenic transformation. Despite significant progress made towards understanding their mechanisms of action, much less is known about the regulation of expression of specific microRNAs. Recent reports have established a link between hypoxia, a key feature of the tumor microenvironment, and a group of microRNAs. Select members of this group seem to affect apoptotic signaling in a hypoxic environment and are also predicted to target genes of critical importance for tumor biology. Interestingly, most hypoxia-induced microRNAs are also overexpressed in human cancers, suggesting a role in tumorigenesis. We hereby discuss the known and predicted regulators of microRNA expression and approaches for expanding this fledgling research area.

Original languageEnglish (US)
Pages (from-to)1426-1431
Number of pages6
JournalCell Cycle
Volume6
Issue number12
StatePublished - Jun 15 2007
Externally publishedYes

Fingerprint

MicroRNAs
Tumors
Neoplastic Cell Transformation
Tumor Microenvironment
Pathologic Processes
Neoplasms
Carcinogenesis
Genes
Research
Hypoxia

Keywords

  • Cancer
  • Expression profiles
  • Hypoxia
  • microRNA
  • Regulation
  • Target genes

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology
  • Medicine(all)

Cite this

Kulshreshtha, R., Ferracin, M., Negrini, M., Calin, G. A., Davuluri, R. V., & Ivan, M. (2007). Regulation of microRNA expression: The hypoxic component. Cell Cycle, 6(12), 1426-1431.

Regulation of microRNA expression : The hypoxic component. / Kulshreshtha, Ritu; Ferracin, Manuela; Negrini, Massimo; Calin, George A.; Davuluri, Ramana V.; Ivan, Mircea.

In: Cell Cycle, Vol. 6, No. 12, 15.06.2007, p. 1426-1431.

Research output: Contribution to journalArticle

Kulshreshtha, R, Ferracin, M, Negrini, M, Calin, GA, Davuluri, RV & Ivan, M 2007, 'Regulation of microRNA expression: The hypoxic component', Cell Cycle, vol. 6, no. 12, pp. 1426-1431.
Kulshreshtha R, Ferracin M, Negrini M, Calin GA, Davuluri RV, Ivan M. Regulation of microRNA expression: The hypoxic component. Cell Cycle. 2007 Jun 15;6(12):1426-1431.
Kulshreshtha, Ritu ; Ferracin, Manuela ; Negrini, Massimo ; Calin, George A. ; Davuluri, Ramana V. ; Ivan, Mircea. / Regulation of microRNA expression : The hypoxic component. In: Cell Cycle. 2007 ; Vol. 6, No. 12. pp. 1426-1431.
@article{faa9eb5d93b344e3870953aad59e84ed,
title = "Regulation of microRNA expression: The hypoxic component",
abstract = "microRNAs are involved in a wide variety of normal and pathological cellular processes, including tumorigenic transformation. Despite significant progress made towards understanding their mechanisms of action, much less is known about the regulation of expression of specific microRNAs. Recent reports have established a link between hypoxia, a key feature of the tumor microenvironment, and a group of microRNAs. Select members of this group seem to affect apoptotic signaling in a hypoxic environment and are also predicted to target genes of critical importance for tumor biology. Interestingly, most hypoxia-induced microRNAs are also overexpressed in human cancers, suggesting a role in tumorigenesis. We hereby discuss the known and predicted regulators of microRNA expression and approaches for expanding this fledgling research area.",
keywords = "Cancer, Expression profiles, Hypoxia, microRNA, Regulation, Target genes",
author = "Ritu Kulshreshtha and Manuela Ferracin and Massimo Negrini and Calin, {George A.} and Davuluri, {Ramana V.} and Mircea Ivan",
year = "2007",
month = "6",
day = "15",
language = "English (US)",
volume = "6",
pages = "1426--1431",
journal = "Cell Cycle",
issn = "1538-4101",
publisher = "Landes Bioscience",
number = "12",

}

TY - JOUR

T1 - Regulation of microRNA expression

T2 - The hypoxic component

AU - Kulshreshtha, Ritu

AU - Ferracin, Manuela

AU - Negrini, Massimo

AU - Calin, George A.

AU - Davuluri, Ramana V.

AU - Ivan, Mircea

PY - 2007/6/15

Y1 - 2007/6/15

N2 - microRNAs are involved in a wide variety of normal and pathological cellular processes, including tumorigenic transformation. Despite significant progress made towards understanding their mechanisms of action, much less is known about the regulation of expression of specific microRNAs. Recent reports have established a link between hypoxia, a key feature of the tumor microenvironment, and a group of microRNAs. Select members of this group seem to affect apoptotic signaling in a hypoxic environment and are also predicted to target genes of critical importance for tumor biology. Interestingly, most hypoxia-induced microRNAs are also overexpressed in human cancers, suggesting a role in tumorigenesis. We hereby discuss the known and predicted regulators of microRNA expression and approaches for expanding this fledgling research area.

AB - microRNAs are involved in a wide variety of normal and pathological cellular processes, including tumorigenic transformation. Despite significant progress made towards understanding their mechanisms of action, much less is known about the regulation of expression of specific microRNAs. Recent reports have established a link between hypoxia, a key feature of the tumor microenvironment, and a group of microRNAs. Select members of this group seem to affect apoptotic signaling in a hypoxic environment and are also predicted to target genes of critical importance for tumor biology. Interestingly, most hypoxia-induced microRNAs are also overexpressed in human cancers, suggesting a role in tumorigenesis. We hereby discuss the known and predicted regulators of microRNA expression and approaches for expanding this fledgling research area.

KW - Cancer

KW - Expression profiles

KW - Hypoxia

KW - microRNA

KW - Regulation

KW - Target genes

UR - http://www.scopus.com/inward/record.url?scp=36849077497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36849077497&partnerID=8YFLogxK

M3 - Article

C2 - 17582223

AN - SCOPUS:36849077497

VL - 6

SP - 1426

EP - 1431

JO - Cell Cycle

JF - Cell Cycle

SN - 1538-4101

IS - 12

ER -