Regulation of osteoclast differentiation

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

The osteoclast (OCL) is derived from the cells in monocyte-macrophage lineage. The earliest identifiable OCL precursor is the granulocyte-macrophage colony-forming unit (CFU-GM), which gives rise to granulocytes, monocytes, and OCL. CFU-GM-derived cells then differentiate to committed OCL precursors, which are post-mitotic cells, and fuse to form multinucleated OCL. A variety of factors both positively and negatively regulate OCL formation and activity. These include growth factors, such as macrophage colony-simulating factor, which simulates the proliferation and prevents apoptosis of early OCL precursors, and RANK ligand (RANKL), which is the primary mediator of OCL formation. Most factors that induce OCL differentiation, such as PTHrP, IL-11, and prostaglandins, do so by inducing expression of RANKL on the surface of immature osteoblasts. Osteoprotegerin is a decoy receptor that blocks RANKL activity. In addition, OCL produce autocrine-paracrine factors that regulate OCL formation, such as IL-6, which is produced at high levels by OCL in Paget's disease and increases OCL formation. We screened human and murine OCL cDNA libraries to identify autocrine-paracrine factors that regulate OCL activity. We identified annexin-II, MIP-1α, ADAM8, eosinophil chemotactic factor, and OCL inhibitor factors 1 and 2 as factors involved in OCL formation. Most recently, we have identified the receptor for ADAM8, α9β1 integrin, which appears to be critical for normal OCL activity. OCL differentiation is controlled by exogenous hormones and cytokines as well as autocrine-paracrine factors that positively or negatively regulate OCL proliferation and differentiation.

Original languageEnglish (US)
Pages (from-to)100-109
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume1068
Issue number1
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Osteoclasts
RANK Ligand
Granulocyte-Macrophage Progenitor Cells
Macrophages
Monocytes
Precursor
Cells
Eosinophil Chemotactic Factors
Annexin A2
Interleukin-11
Parathyroid Hormone-Related Protein
Osteoprotegerin
Osteoblasts
Colonies
Electric fuses

Keywords

  • Autocrine
  • Cytokines
  • Differentiation
  • Osteoclasts
  • Paracrine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Regulation of osteoclast differentiation. / Roodman, G. David.

In: Annals of the New York Academy of Sciences, Vol. 1068, No. 1, 04.2006, p. 100-109.

Research output: Contribution to journalArticle

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