Regulation of oxidative activity and Δψ of liver mitochondria of active and hibernating gophers. The role of phospholipase A2

Nikolai Broustovetski, M. V. Egorova, E. I. Mayevsky

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

1. 1. In the present work the initially lowered oxidase activity of liver mitochondria of hibernating gophers is shown to increase upon Ca2+-loading, after freezing-thawing repeated three times and after swelling in a medium containing potassium acetate as well as in a hypotonic sucrose medium. 2. 2. In all cases the inhibition of phospholipase A2 hindered the increase of the oxidase activity of mitochondria. 3. 3. Mitochondria of hibernating gophers have a lowered Δψ in comparison with active animals, which is restored in the hypotonic medium.

Original languageEnglish (US)
Pages (from-to)635-638
Number of pages4
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume102
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Gophers
Mitochondria
Liver Mitochondrion
Phospholipases A2
Liver
Oxidoreductases
Potassium Acetate
Freezing
Sucrose
Thawing
Swelling
Animals

ASJC Scopus subject areas

  • Biochemistry
  • Physiology

Cite this

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T1 - Regulation of oxidative activity and Δψ of liver mitochondria of active and hibernating gophers. The role of phospholipase A2

AU - Broustovetski, Nikolai

AU - Egorova, M. V.

AU - Mayevsky, E. I.

PY - 1992

Y1 - 1992

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AB - 1. 1. In the present work the initially lowered oxidase activity of liver mitochondria of hibernating gophers is shown to increase upon Ca2+-loading, after freezing-thawing repeated three times and after swelling in a medium containing potassium acetate as well as in a hypotonic sucrose medium. 2. 2. In all cases the inhibition of phospholipase A2 hindered the increase of the oxidase activity of mitochondria. 3. 3. Mitochondria of hibernating gophers have a lowered Δψ in comparison with active animals, which is restored in the hypotonic medium.

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