Regulation of pyruvate metabolism in metabolic-related diseases

Nam Ho Jeoung, Chris R. Harris, Robert Harris

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Pyruvate is an obligatory intermediate in the oxidative disposal of glucose and a major precursor for the synthesis of glucose, glycerol, fatty acids, and non-essential amino acids. Stringent control of the fate of pyruvate is critically important for cellular homeostasis. The regulatory mechanisms for its metabolism are therefore of great interest. Recent advances include the findings that (a) the mitochondrial pyruvate carrier is sensitive to inhibition by thiazolidinediones; (b) pyruvate dehydrogenase kinases induce the Warburg effect in many disease states; and (c) pyruvate carboxylase is an important determinate of the rates of gluconeogenesis in humans with type 2 diabetes. These enzymes are potential therapeutic targets for several diseases.

Original languageEnglish
Pages (from-to)99-110
Number of pages12
JournalReviews in Endocrine and Metabolic Disorders
Volume15
Issue number1
DOIs
StatePublished - 2014

Fingerprint

Metabolic Diseases
Pyruvic Acid
Pyruvate Carboxylase
Glucose
Thiazolidinediones
Essential Fatty Acids
Gluconeogenesis
Glycerol
Type 2 Diabetes Mellitus
Homeostasis
Amino Acids
Enzymes
Therapeutics
pyruvate dehydrogenase (acetyl-transferring) kinase
pyruvate transport protein

Keywords

  • Dichloroacetate
  • Gluconeogenesis
  • Mitochondrial pyruvate carrier
  • Pyruvate carboxylase
  • Pyruvate dehydrogenase complex
  • Pyruvate dehydrogenase kinase
  • Thiazolidione

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Regulation of pyruvate metabolism in metabolic-related diseases. / Jeoung, Nam Ho; Harris, Chris R.; Harris, Robert.

In: Reviews in Endocrine and Metabolic Disorders, Vol. 15, No. 1, 2014, p. 99-110.

Research output: Contribution to journalArticle

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