Regulation of pyruvate metabolism in metabolic-related diseases

Nam Ho Jeoung, Chris R. Harris, Robert A. Harris

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Pyruvate is an obligatory intermediate in the oxidative disposal of glucose and a major precursor for the synthesis of glucose, glycerol, fatty acids, and non-essential amino acids. Stringent control of the fate of pyruvate is critically important for cellular homeostasis. The regulatory mechanisms for its metabolism are therefore of great interest. Recent advances include the findings that (a) the mitochondrial pyruvate carrier is sensitive to inhibition by thiazolidinediones; (b) pyruvate dehydrogenase kinases induce the Warburg effect in many disease states; and (c) pyruvate carboxylase is an important determinate of the rates of gluconeogenesis in humans with type 2 diabetes. These enzymes are potential therapeutic targets for several diseases.

Original languageEnglish (US)
Pages (from-to)99-110
Number of pages12
JournalReviews in Endocrine and Metabolic Disorders
Volume15
Issue number1
DOIs
StatePublished - Mar 2014

Keywords

  • Dichloroacetate
  • Gluconeogenesis
  • Mitochondrial pyruvate carrier
  • Pyruvate carboxylase
  • Pyruvate dehydrogenase complex
  • Pyruvate dehydrogenase kinase
  • Thiazolidione

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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