Regulation of Qa-1 expression and determinant modification by an H-2D-linked gene, Qdm

Carla J. Aldrich, John R. Rodgers, Robert R. Rich

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

We examined the regulation of cell surface expression of the Qa-1 alloantigens using a panel of monoclonal anti-Qa-1 cytotoxic T-lymphocyte (mCTL) lines. In contrast to previous reports of tissue-specific expression, we found that Qa-1 was widely expressed, resembling the prototypical class I H-2K/D molecules. We further found that an H-2D-linked gene, which we termed Qdm for Qa-1 determinant modifier, controlled expression of certain CTL-defined Qa-1 antigenic determinants. H-2Dkhomozygous haplotypes expressed a recessive allele of the modifier, Qdmk, whereas all other H-2 haplotypes tested expressed a dominant allele, Qdm+. The Qdm+ allele regulated in trans Qa-1 epitope expression from a Qdmkchromosome, modifying expression of particular CTL-defined Qa-1 antigenic determinants rather than affecting levels of cell surface expression. Mechanisms of Qdm function may include either a novel protein modification system or an unprecedented case of antigen recognition restricted by a nonclassical major histocompatibility complex molecule.

Original languageEnglish (US)
Pages (from-to)334-344
Number of pages11
JournalImmunogenetics
Volume28
Issue number5
DOIs
StatePublished - Nov 1 1988

ASJC Scopus subject areas

  • Immunology
  • Genetics

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