Regulation of retinal and optic nerve blood flow

Alon Harris, Thomas A. Ciulla, Hak Sung Chung, Bruce Martin

Research output: Contribution to journalReview article

95 Scopus citations


Blood flow to the retina and optic nerve remains constant over a range of elevated intraocular pressure or mean arterial pressure, independent of sympathetic activation (pressure autoregulation). In addition, increased metabolic activity in these tissues proportionally increases blood flow (metabolic autoregulation). At constant metabolic rate, altered arterial oxygen content reciprocally alters blood flow, leaving total oxygen delivery constant, while blood flow rises and falls with the arterial carbon dioxide tension. These responses are similar to those of the cerebral circulation. However, while aging, atherosclerosis, arterial hypotension, and individual variation may profoundly alter blood flow regulation and predispose to the development of illness, these factors remain largely unexplored.

Original languageEnglish (US)
Pages (from-to)1491-1495
Number of pages5
JournalArchives of Ophthalmology
Issue number11
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Regulation of retinal and optic nerve blood flow'. Together they form a unique fingerprint.

  • Cite this