Regulation of retinal and optic nerve blood flow

Alon Harris, Thomas A. Ciulla, Hak Sung Chung, Bruce Martin

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Blood flow to the retina and optic nerve remains constant over a range of elevated intraocular pressure or mean arterial pressure, independent of sympathetic activation (pressure autoregulation). In addition, increased metabolic activity in these tissues proportionally increases blood flow (metabolic autoregulation). At constant metabolic rate, altered arterial oxygen content reciprocally alters blood flow, leaving total oxygen delivery constant, while blood flow rises and falls with the arterial carbon dioxide tension. These responses are similar to those of the cerebral circulation. However, while aging, atherosclerosis, arterial hypotension, and individual variation may profoundly alter blood flow regulation and predispose to the development of illness, these factors remain largely unexplored.

Original languageEnglish
Pages (from-to)1491-1495
Number of pages5
JournalArchives of Ophthalmology
Volume116
Issue number11
StatePublished - 1998

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Optic Nerve
Cerebrovascular Circulation
Homeostasis
Oxygen
Intraocular Pressure
Carbon Dioxide
Hypotension
Retina
Atherosclerosis
Arterial Pressure
Pressure

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Harris, A., Ciulla, T. A., Chung, H. S., & Martin, B. (1998). Regulation of retinal and optic nerve blood flow. Archives of Ophthalmology, 116(11), 1491-1495.

Regulation of retinal and optic nerve blood flow. / Harris, Alon; Ciulla, Thomas A.; Chung, Hak Sung; Martin, Bruce.

In: Archives of Ophthalmology, Vol. 116, No. 11, 1998, p. 1491-1495.

Research output: Contribution to journalArticle

Harris, A, Ciulla, TA, Chung, HS & Martin, B 1998, 'Regulation of retinal and optic nerve blood flow', Archives of Ophthalmology, vol. 116, no. 11, pp. 1491-1495.
Harris A, Ciulla TA, Chung HS, Martin B. Regulation of retinal and optic nerve blood flow. Archives of Ophthalmology. 1998;116(11):1491-1495.
Harris, Alon ; Ciulla, Thomas A. ; Chung, Hak Sung ; Martin, Bruce. / Regulation of retinal and optic nerve blood flow. In: Archives of Ophthalmology. 1998 ; Vol. 116, No. 11. pp. 1491-1495.
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