Regulation of retinal blood flow during blood gas perturbation

Alon Harris, Bruce J. Martin, John A. Shoemaker

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In this review, we discuss the regulation of ocular blood flow, the role it may play in disease, and the physiologic methods used to assess it. Altered perfusion may play a role in several ocular diseases. In particular, derangements in ocular blood flow have been offered as possible factors in the development of glaucomatous optic neuropathy. In fact, recent studies have suggested that glaucomatous eyes may lack the degree of circulatory autoregulation found in healthy eyes. The autoregulation of ocular blood flow is in response to tissue pressure, myogenic changes, and metabolic levels. To assess the eye’s vascular autoregulation, physiologic perturbation of these mechanisms during hemodynamic assessment provides an autoregulatory “stress test.” Along these lines, we have refined the technique of altering arterial levels of oxygen and carbon dioxide, thus provoking a metabolic autoregulatory response, during measures of blood velocities in ocular vessels. Using somewhat similar methods, others have documented changes in ocular hemodynamics by altering blood gas levels. Results of our own work suggest that retinal blood flow may be regulated to maintain constant oxygen delivery. Likewise, our studies using carbon dioxide suggest that retinal blood flow may be steeply dependant on Pco<inf>2</inf>, for these results to be placed in their proper context, future studies directed at better defining normal autoregulation are needed.

Original languageEnglish
Pages (from-to)S82-S90
JournalJournal of Glaucoma
Volume3
StatePublished - 1994

Fingerprint

Gases
Homeostasis
Carbon Dioxide
Hemodynamics
Oxygen
Optic Nerve Diseases
Eye Diseases
Exercise Test
Blood Vessels
Perfusion
Pressure

Keywords

  • Autoregulation
  • Carbon dioxide
  • Glaucoma
  • Oxygen
  • Retinal blood flow

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Regulation of retinal blood flow during blood gas perturbation. / Harris, Alon; Martin, Bruce J.; Shoemaker, John A.

In: Journal of Glaucoma, Vol. 3, 1994, p. S82-S90.

Research output: Contribution to journalArticle

Harris, A, Martin, BJ & Shoemaker, JA 1994, 'Regulation of retinal blood flow during blood gas perturbation', Journal of Glaucoma, vol. 3, pp. S82-S90.
Harris, Alon ; Martin, Bruce J. ; Shoemaker, John A. / Regulation of retinal blood flow during blood gas perturbation. In: Journal of Glaucoma. 1994 ; Vol. 3. pp. S82-S90.
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