Regulation of the rate of respiration and oxidative phosphorylation in liver mitochondria from hibernating ground squirrels, Citallus undulatus

Nikolai Broustovetski, E. I. Mayevsky, E. V. Grishina, V. G. Gogvadze, Z. G. Amerkhanov

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

1. 1. The rates of oxidation of various substrates (β-hydroxybutyrate, succinate, ascorbate + TMPD) and the rate of ATP synthesis in liver mitochondria from active and hibernating ground squirrels were measured. 2. 2. It was shown that the rate of mitochondrial respiration is significantly lower in hibernating animals than in active animals. 3. 3. The degree of inhibition of mitochondrial respiration in hibernating ground squirrels was found to correlate with the length of the respiratory chain fragment involved in the oxidation of a given substrate. 4. 4. The inhibition of mitochondrial respiration in hibernating animals was accompanied by a decrease in the rate of ATP synthesis. 5. 5. The activity of phospholipase A2 in liver mitochondria from hibernating ground squirrels was found to be decreased. The activation of phospholipase A2 by Ca2+ ions eliminated the inhibition of respiration almost completely. 6. 6. It was assumed that the inhibition of mitochondrial respiration during hibernation is (a) related to the suppression of phospholipase A2 activity and (b) caused by the reduced rates of electron transport through the respiratory chain and/or of substrate transport across the mitochondrial membrane.

Original languageEnglish (US)
Pages (from-to)537-541
Number of pages5
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume94
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Sciuridae
Mitochondria
Liver Mitochondrion
Phospholipases A2
Oxidative Phosphorylation
Respiratory Rate
Liver
Respiration
Animals
Electron Transport
Substrates
Adenosine Triphosphate
Hydroxybutyrates
Oxidation
Succinic Acid
Hibernation
Mitochondrial Membranes
Chemical activation
Ions
Membranes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Regulation of the rate of respiration and oxidative phosphorylation in liver mitochondria from hibernating ground squirrels, Citallus undulatus. / Broustovetski, Nikolai; Mayevsky, E. I.; Grishina, E. V.; Gogvadze, V. G.; Amerkhanov, Z. G.

In: Comparative Biochemistry and Physiology -- Part B: Biochemistry and, Vol. 94, No. 3, 1989, p. 537-541.

Research output: Contribution to journalArticle

@article{74c818d56b85438eafe0cfa2a0db90d1,
title = "Regulation of the rate of respiration and oxidative phosphorylation in liver mitochondria from hibernating ground squirrels, Citallus undulatus",
abstract = "1. 1. The rates of oxidation of various substrates (β-hydroxybutyrate, succinate, ascorbate + TMPD) and the rate of ATP synthesis in liver mitochondria from active and hibernating ground squirrels were measured. 2. 2. It was shown that the rate of mitochondrial respiration is significantly lower in hibernating animals than in active animals. 3. 3. The degree of inhibition of mitochondrial respiration in hibernating ground squirrels was found to correlate with the length of the respiratory chain fragment involved in the oxidation of a given substrate. 4. 4. The inhibition of mitochondrial respiration in hibernating animals was accompanied by a decrease in the rate of ATP synthesis. 5. 5. The activity of phospholipase A2 in liver mitochondria from hibernating ground squirrels was found to be decreased. The activation of phospholipase A2 by Ca2+ ions eliminated the inhibition of respiration almost completely. 6. 6. It was assumed that the inhibition of mitochondrial respiration during hibernation is (a) related to the suppression of phospholipase A2 activity and (b) caused by the reduced rates of electron transport through the respiratory chain and/or of substrate transport across the mitochondrial membrane.",
author = "Nikolai Broustovetski and Mayevsky, {E. I.} and Grishina, {E. V.} and Gogvadze, {V. G.} and Amerkhanov, {Z. G.}",
year = "1989",
doi = "10.1016/0305-0491(89)90193-4",
language = "English (US)",
volume = "94",
pages = "537--541",
journal = "Comparative Biochemistry and Physiology -- Part B: Biochemistry and",
issn = "0305-0491",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - Regulation of the rate of respiration and oxidative phosphorylation in liver mitochondria from hibernating ground squirrels, Citallus undulatus

AU - Broustovetski, Nikolai

AU - Mayevsky, E. I.

AU - Grishina, E. V.

AU - Gogvadze, V. G.

AU - Amerkhanov, Z. G.

PY - 1989

Y1 - 1989

N2 - 1. 1. The rates of oxidation of various substrates (β-hydroxybutyrate, succinate, ascorbate + TMPD) and the rate of ATP synthesis in liver mitochondria from active and hibernating ground squirrels were measured. 2. 2. It was shown that the rate of mitochondrial respiration is significantly lower in hibernating animals than in active animals. 3. 3. The degree of inhibition of mitochondrial respiration in hibernating ground squirrels was found to correlate with the length of the respiratory chain fragment involved in the oxidation of a given substrate. 4. 4. The inhibition of mitochondrial respiration in hibernating animals was accompanied by a decrease in the rate of ATP synthesis. 5. 5. The activity of phospholipase A2 in liver mitochondria from hibernating ground squirrels was found to be decreased. The activation of phospholipase A2 by Ca2+ ions eliminated the inhibition of respiration almost completely. 6. 6. It was assumed that the inhibition of mitochondrial respiration during hibernation is (a) related to the suppression of phospholipase A2 activity and (b) caused by the reduced rates of electron transport through the respiratory chain and/or of substrate transport across the mitochondrial membrane.

AB - 1. 1. The rates of oxidation of various substrates (β-hydroxybutyrate, succinate, ascorbate + TMPD) and the rate of ATP synthesis in liver mitochondria from active and hibernating ground squirrels were measured. 2. 2. It was shown that the rate of mitochondrial respiration is significantly lower in hibernating animals than in active animals. 3. 3. The degree of inhibition of mitochondrial respiration in hibernating ground squirrels was found to correlate with the length of the respiratory chain fragment involved in the oxidation of a given substrate. 4. 4. The inhibition of mitochondrial respiration in hibernating animals was accompanied by a decrease in the rate of ATP synthesis. 5. 5. The activity of phospholipase A2 in liver mitochondria from hibernating ground squirrels was found to be decreased. The activation of phospholipase A2 by Ca2+ ions eliminated the inhibition of respiration almost completely. 6. 6. It was assumed that the inhibition of mitochondrial respiration during hibernation is (a) related to the suppression of phospholipase A2 activity and (b) caused by the reduced rates of electron transport through the respiratory chain and/or of substrate transport across the mitochondrial membrane.

UR - http://www.scopus.com/inward/record.url?scp=0024780745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024780745&partnerID=8YFLogxK

U2 - 10.1016/0305-0491(89)90193-4

DO - 10.1016/0305-0491(89)90193-4

M3 - Article

VL - 94

SP - 537

EP - 541

JO - Comparative Biochemistry and Physiology -- Part B: Biochemistry and

JF - Comparative Biochemistry and Physiology -- Part B: Biochemistry and

SN - 0305-0491

IS - 3

ER -