Our comparative studies of the expression of all seven human ADH genes (and of the homologous mouse genes) have shown common features and individual diversity. Proximal promoters of the six tissue-specific genes show some cell-type differences in expression, but none shows the degree of specificity found in vivo. Despite major differences among their promoters, these six genes have both TATA-boxes and C/EBP sites as important cis-acting elements in common. We are continuing our studies to locate other cis-acting elements that contribute to tissue specificity, and to identify the transcription factors that bind to and regulate them. We are also examining the surprisingly complex set of cis-acting elements that regulates the ubiquitously expressed ADH5 gene and determines its level of expression in different tissues. Studies on the members of the ADH gene family will illuminate the evolution of tissue-specificity.
|Original language||English (US)|
|Number of pages||7|
|Journal||Advances in experimental medicine and biology|
|State||Published - Apr 1 1997|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)