Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p

Wayne A. Wilson, Zhong Wang, Peter Roach

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Yeast accumulate glycogen in response to nutrient limitation. The key enzymes of glycogen synthesis and degradation, glycogen synthase, and phosphorylase, are regulated by reversible phosphorylation. Phosphorylation inactivates glycogen synthase but activates phosphorylase. The kinases and phosphatases that control glycogen synthase are well characterized whilst the enzymes modifying phosphorylase are poorly defined. Here, we show that the cyclin-dependent protein kinase, Pho85p, which we have previously found to regulate glycogen synthase also controls the phosphorylation state of phosphorylase.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume329
Issue number1
DOIs
StatePublished - Apr 1 2005

Fingerprint

Glycogen Phosphorylase
Glycogen Synthase
Cyclin-Dependent Kinases
Phosphorylases
Yeast
Phosphorylation
Yeasts
Glycogen
Enzymes
Phosphoric Monoester Hydrolases
Nutrients
Phosphotransferases
Food
Degradation

Keywords

  • Glycogen
  • Pho85p
  • Phosphorylase
  • Regulation
  • Yeast

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p. / Wilson, Wayne A.; Wang, Zhong; Roach, Peter.

In: Biochemical and Biophysical Research Communications, Vol. 329, No. 1, 01.04.2005, p. 161-167.

Research output: Contribution to journalArticle

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