Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p

Wayne A. Wilson, Zhong Wang, Peter J. Roach

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Yeast accumulate glycogen in response to nutrient limitation. The key enzymes of glycogen synthesis and degradation, glycogen synthase, and phosphorylase, are regulated by reversible phosphorylation. Phosphorylation inactivates glycogen synthase but activates phosphorylase. The kinases and phosphatases that control glycogen synthase are well characterized whilst the enzymes modifying phosphorylase are poorly defined. Here, we show that the cyclin-dependent protein kinase, Pho85p, which we have previously found to regulate glycogen synthase also controls the phosphorylation state of phosphorylase.

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume329
Issue number1
DOIs
StatePublished - Apr 1 2005

Keywords

  • Glycogen
  • Pho85p
  • Phosphorylase
  • Regulation
  • Yeast

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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