Regulators of the metabolism of l-asparagine

A search for endogenous inhibitors

David A. Cooney, Michael T. Jones, Harry A. Milman, David M. Young, Hiremagalur N. Jayaram

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

1. 1. A study of over 400 intermediary metabolites and naturally occurring macromolecules has been carried out in an attempt to identify molecules capable of regulating the metabolism of l-asparagine. 2. 2. Test systems consisting of mouse hepatic and testicular l-asparaginase, as well as, mouse pancreatic and tumoral l-asparagine synthetase, were used. 3. 3. Selective inhibitors have been categorized as-trace elements; amino acids, analogs and peptides; nucleic acid bases, nucleosides and nucleotides; aldehydes, lipids, porphyrins and pigments; vitamins and coenzymes; proteinaceous materials; citric acid cycle intermediates and related molecules; carbohydrates; and miscellaneous agents. 4. 4. An attempt has been made to extrapolate these in vitro studies to the regulation of the metabolism of l-asparagine in vivo.

Original languageEnglish (US)
Pages (from-to)519-539
Number of pages21
JournalInternational Journal of Biochemistry
Volume11
Issue number6
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Asparagine
Metabolism
Nucleic Acids, Nucleotides, and Nucleosides
Aspartate-Ammonia Ligase
Asparaginase
Molecules
Citric Acid Cycle
Coenzymes
Porphyrins
Trace Elements
Metabolites
Macromolecules
Nucleosides
Aldehydes
Pigments
Vitamins
Nucleic Acids
Nucleotides
Carbohydrates
Lipids

ASJC Scopus subject areas

  • Biochemistry

Cite this

Regulators of the metabolism of l-asparagine : A search for endogenous inhibitors. / Cooney, David A.; Jones, Michael T.; Milman, Harry A.; Young, David M.; Jayaram, Hiremagalur N.

In: International Journal of Biochemistry, Vol. 11, No. 6, 1980, p. 519-539.

Research output: Contribution to journalArticle

Cooney, David A. ; Jones, Michael T. ; Milman, Harry A. ; Young, David M. ; Jayaram, Hiremagalur N. / Regulators of the metabolism of l-asparagine : A search for endogenous inhibitors. In: International Journal of Biochemistry. 1980 ; Vol. 11, No. 6. pp. 519-539.
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